Effect of an H5N1 avian influenza virus infection on the immune system of mallard ducks.

E. Laudert, V. Sivanandan, D. Halvorson

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Avian influenza virus (AIV) of waterfowl origin, A/Mallard/Ohio/184/86 (H5N1), was used to evaluate the effect of AIV infection on the functional capabilities of the immune system in mallard ducks. The three main arms of the immune system--humoral, cell-mediated, and cellular--were evaluated. The integrity of the humoral immune system after AIV infection was evaluated by measuring total immunoglobulin and IgG antibody production to sheep erythrocytes and Brucella abortus antigen using hemagglutination and microagglutination assays, respectively. Cell-mediated immunity was evaluated using mitogen/antigen stimulation assays, and by measuring the cutaneous basophilic hypersensitivity response to intradermal phytohemagglutinin-P inoculation. The cellular component of the immune response was evaluated using whole-blood chemiluminescence and bacterial clearance assays. Results showed that infection with this AIV isolate suppressed T-cell function and enhanced macrophage phagocytic activity.

Original languageEnglish (US)
Pages (from-to)845-853
Number of pages9
JournalAvian diseases
Issue number3
StatePublished - Jan 1 1993


Dive into the research topics of 'Effect of an H5N1 avian influenza virus infection on the immune system of mallard ducks.'. Together they form a unique fingerprint.

Cite this