TY - JOUR
T1 - Effect of amlodipine on mesangial cell proliferation ana protein synthesis
AU - Shultz, Pamela J.
AU - Raij, Leopoldo
PY - 1992/12
Y1 - 1992/12
N2 - Mesangial cells in the glomerulus have several important physiological functions, as has been demonstrated by past research. Platelet derived growth factor, thrombin, endothelin, and angiotensin II have all been shown to affect mesangial cell growth and protein synthesis. First generation Ca channel blockers also have a definite effect on mesangial cell proliferation. We investigated whether the effects of a second generation Ca channel blocker, amlodipine, were similar. Amlodipine was found to inhibit hyperplasia and hypertrophy in mesangial cells.
AB - Mesangial cells in the glomerulus have several important physiological functions, as has been demonstrated by past research. Platelet derived growth factor, thrombin, endothelin, and angiotensin II have all been shown to affect mesangial cell growth and protein synthesis. First generation Ca channel blockers also have a definite effect on mesangial cell proliferation. We investigated whether the effects of a second generation Ca channel blocker, amlodipine, were similar. Amlodipine was found to inhibit hyperplasia and hypertrophy in mesangial cells.
KW - Calcium channel blocker
KW - Endothelin
KW - Platelet derived growth factor
KW - [H]leucine
KW - [H]thymidine
UR - https://www.scopus.com/pages/publications/0027053486
UR - https://www.scopus.com/inward/citedby.url?scp=0027053486&partnerID=8YFLogxK
U2 - 10.1093/ajh/5.12.912
DO - 10.1093/ajh/5.12.912
M3 - Article
C2 - 1285940
AN - SCOPUS:0027053486
SN - 0895-7061
VL - 5
SP - 912
EP - 914
JO - American journal of hypertension
JF - American journal of hypertension
IS - 12
ER -