TY - JOUR
T1 - Effect of alendronate on orthodontic tooth movement in rats
AU - Karras, Jeremy C.
AU - Miller, James R.
AU - Hodges, James S.
AU - Beyer, John P.
AU - Larson, Brent E.
PY - 2009/12
Y1 - 2009/12
N2 - Introduction: Osteoclastic activity is required for orthodontic force to move teeth through alveolar bone. Bisphosphonates are drugs that inhibit osteoclast maturation, function, and survival. The aim of this study was to assess orthodontic tooth movement in rats receiving bisphosphonate treatment. Methods: Two groups of Sprague-Dawley rats were used. The rats in the treatment group received 7 mg per kilogram of body weight per week of alendronate sodium, and those in the control group received no drugs. A coil spring exerting a constant 50-g force was activated across the span from the central incisors to the first molar. As the first molar tipped mesially, a diastema between the first and second molars was created. Vinyl polysiloxane impressions were poured in die stone, and the diastema was measured indirectly with a charged-couple device microscope camera and Optimas software (Media Cybernetics, Newburyport, Mass). Results: Statistical analysis with repeated-measures analysis of variance showed less orthodontic tooth movement in the alendronate group compared with control group (0.06 vs 0.24 mm at 2 weeks, and 0.45 vs 1.06 mm at 4 weeks; P = 0.0004 for the alendronate vs control main effect). Conclusions: This study demonstrated an inhibitory effect of alendronate administration on orthodontic tooth movement in a rat model.
AB - Introduction: Osteoclastic activity is required for orthodontic force to move teeth through alveolar bone. Bisphosphonates are drugs that inhibit osteoclast maturation, function, and survival. The aim of this study was to assess orthodontic tooth movement in rats receiving bisphosphonate treatment. Methods: Two groups of Sprague-Dawley rats were used. The rats in the treatment group received 7 mg per kilogram of body weight per week of alendronate sodium, and those in the control group received no drugs. A coil spring exerting a constant 50-g force was activated across the span from the central incisors to the first molar. As the first molar tipped mesially, a diastema between the first and second molars was created. Vinyl polysiloxane impressions were poured in die stone, and the diastema was measured indirectly with a charged-couple device microscope camera and Optimas software (Media Cybernetics, Newburyport, Mass). Results: Statistical analysis with repeated-measures analysis of variance showed less orthodontic tooth movement in the alendronate group compared with control group (0.06 vs 0.24 mm at 2 weeks, and 0.45 vs 1.06 mm at 4 weeks; P = 0.0004 for the alendronate vs control main effect). Conclusions: This study demonstrated an inhibitory effect of alendronate administration on orthodontic tooth movement in a rat model.
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U2 - 10.1016/j.ajodo.2007.11.035
DO - 10.1016/j.ajodo.2007.11.035
M3 - Article
C2 - 19962607
AN - SCOPUS:70749093007
SN - 0889-5406
VL - 136
SP - 843
EP - 847
JO - American Journal of Orthodontics and Dentofacial Orthopedics
JF - American Journal of Orthodontics and Dentofacial Orthopedics
IS - 6
ER -