Effect of ageing on circadian rhythms of plasma renin and aldosterone in mesor-hypertensive women

P. Cugini, F. Halberg, R. B. Sothern, Germaine G Cornelissen-Guillaume, M. Lisanu, R. Romassini, P. Lucia, E. Salandi, D. Scavo

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This study investigated the changes in circadian rhythms of plasma renin activity (PRA) and plasma aldosterone (PA) which occur in essential mesor-hypertensive women, increasing in age. Systemic blood samples were taken throughout a 12 h period from both mesor-hypertensive women and clinically healthy women (control). The women in each group were either post-menopausal or had normal menstrual cycles. A cosinor method of temporal series was the analysis employed to compute the properties of PRA and PA circadian rhythms. The clearest effect of ageing, recorded in essential mesor-hypertensive women, is a decrease in circadian mesor of PRA cycle (P = 0.002). The age-related changes in clinically healthy women appear to be more extensive and involve a decrease for both mesor (P < 0.001) and amplitude (P = 0.007) of PRA circadian rhythm. These disparities are convincing evidence for a non-physiological decline of the RAAS rhythmic function in the aged essential mesor-hypertensive women. The lack of an age-associated decrease in circadian PRA amplitude merits a pathophysiological and clinical investigation because it is a possible risk factor for post-menopausal, essential mesor-hypertensive women.

Original languageEnglish (US)
Pages (from-to)139-147
Number of pages9
Issue number2
StatePublished - 1982


  • Ageing
  • Aldosterone
  • Angiotensin
  • Circadian rhythm
  • Mesor-hypertension
  • Renin


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