Effect of age on the percentage of hemoglobin A(1c) and the percentage of total glycohemoglobin in non-diabetic persons

Frank Q. Nuttall

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

The purpose of this study was to determine the correlation between age and the percentage of total glycohemoglobin (%tGHb) and that of hemoglobin A(1c) (%HbA(1c)) in an adult population without known diabetes. The %tGHb was determined by a semi-automated gravity elution method and by an automated high, performance liquid chromatography (HPLC) method in 210 and 147 subjects without known diabetes, respectively. The %HbA(1c) was determined by ion-exchange HPLC in 109 subjects without known diabetes. There was a modest age-related increase in %tGHb and %HbA(1c). The mean increase was approximately 0.11% to 0.15% per decade depending on the analytic method used. However, the variance was very large. In conclusion, there is an age-related increase in %tGHb and %HbA(1c). However, the increase is only modest and has only a minor effect on a determined reference range in adults.

Original languageEnglish (US)
Pages (from-to)451-453
Number of pages3
JournalJournal of Laboratory and Clinical Medicine
Volume134
Issue number5
DOIs
StatePublished - 1999

Bibliographical note

Funding Information:
Supported by Merit Review Research Funds from the Department of Veterans Affairs.

Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.

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