Effect of acute uremia on pancreatic insulin stores in rats

Arnold W. Lindall, Robert L Sorenson, Simon L. Cohen, Harold A. Nash, Rafi Younoszai

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

The effect of acute uremia on stores of pancreatic insulin was examined. Four groups of rats were studied: nephrectomized rats on a special low nitrogen diet, sham-nephrectomized rats on the same diet, sham-nephrectomized rats on a normal diet, and normal rats on a normal diet. Uremia created by nephrectomy was allowed to continue for 6 days at which time animals were sacrificed. A period of 10 days of diet equilibration was done prior to nephrectomy. Total body weight, pancreas and liver weights declined in sham-operated and nephrectomized rats mostly attributable to the diet. In uremic rats, however, heart weights increased. Insulin expressed as U/g pancreas, total insulin per animal, U/100 g body weight, or as per cent of protein was significantly depressed in the uremic rats compared to sham-operated special diet controls.

Original languageEnglish (US)
Pages (from-to)86-91
Number of pages6
JournalMetabolism
Volume21
Issue number1
DOIs
StatePublished - Jan 1972

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