Effect of acute morphine administration on the metabolism of brain catecholamines

Horace H. Loh; Robert J. Hitzemann; E. Leong Way

doi:10.1016/0024-3205(73)90171-9

Effect of acute morphine administration on the metabolism of brain catecholamines

Horace H. Loh
, Robert J. Hitzemann
, E. Leong Way

Pharmacology

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

The effects of sub-analgetic and analgetic doses of morphine (5-20 mg/kg) on the metabolism of intravenously administered [¹⁴C]-tyrosine (200 uCi/kg) in the mouse brain were investigated. A significantly increased conversion of [¹⁴C]-tyrosine to the [¹⁴C]-catecholamines was observed only at an analgetic dose of morphine. Furthermore, morphine increased the specific activity of brain [¹⁴C]-tyrosine and this effect was blocked by naloxone, a morphine antagonist.

Original language	English (US)
Pages (from-to)	33-41
Number of pages	9
Journal	Life Sciences
Volume	12
Issue number	1 PART 1
DOIs	https://doi.org/10.1016/0024-3205(73)90171-9
State	Published - Jan 3 1973

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abstract = "The effects of sub-analgetic and analgetic doses of morphine (5-20 mg/kg) on the metabolism of intravenously administered [14C]-tyrosine (200 uCi/kg) in the mouse brain were investigated. A significantly increased conversion of [14C]-tyrosine to the [14C]-catecholamines was observed only at an analgetic dose of morphine. Furthermore, morphine increased the specific activity of brain [14C]-tyrosine and this effect was blocked by naloxone, a morphine antagonist.",

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AU - Hitzemann, Robert J.

AU - Leong Way, E.

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N2 - The effects of sub-analgetic and analgetic doses of morphine (5-20 mg/kg) on the metabolism of intravenously administered [14C]-tyrosine (200 uCi/kg) in the mouse brain were investigated. A significantly increased conversion of [14C]-tyrosine to the [14C]-catecholamines was observed only at an analgetic dose of morphine. Furthermore, morphine increased the specific activity of brain [14C]-tyrosine and this effect was blocked by naloxone, a morphine antagonist.

AB - The effects of sub-analgetic and analgetic doses of morphine (5-20 mg/kg) on the metabolism of intravenously administered [14C]-tyrosine (200 uCi/kg) in the mouse brain were investigated. A significantly increased conversion of [14C]-tyrosine to the [14C]-catecholamines was observed only at an analgetic dose of morphine. Furthermore, morphine increased the specific activity of brain [14C]-tyrosine and this effect was blocked by naloxone, a morphine antagonist.

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UR - https://www.scopus.com/pages/publications/0015912730#tab=citedBy

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JO - Life Sciences

JF - Life Sciences

IS - 1 PART 1

ER -

Effect of acute morphine administration on the metabolism of brain catecholamines

Abstract

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