Effect of acute and chronic ethanol treatment on rat brain phospholipid turnover

Nancy M. Lee, Howard J. Friedman, Horace H. Loh

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

Phospholipid turnover was studied in the rat brain after treatment in vitro with (1) an acute dose of ethanol, (2) after the development of tolerance to ethanol, (3) of physical dependence on ethanol, and (4) of withdrawal from dependence. It was found that the turnover of phosphatidylcholine, of phosphatidylinosotol/phosphatidylserine and of phosphatidylethanolamine was increased in tolerant animals and that tolerance developed to these increases in dependent animals. A drastic decrease in 32P-labeled phosphatidylinositol/phosphatidylserine of microsomal fractions was observed in animals withdrawing from dependence.

Original languageEnglish (US)
Pages (from-to)2815-2818
Number of pages4
JournalBiochemical Pharmacology
Volume29
Issue number20
DOIs
StatePublished - 1980

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