Effect of a lifestyle intervention on change in cardiorespiratory fitness in adults with type 2 diabetes: Results from the Look AHEAD Study

J. M. Jakicic; S. A. Jaramillo; A. Balasubramanyam; B. Bancroft; J. M. Curtis; A. Mathews; M. Pereira; J. G. Regensteiner; P. M. Ribisl

doi:10.1038/ijo.2008.280

Effect of a lifestyle intervention on change in cardiorespiratory fitness in adults with type 2 diabetes: Results from the Look AHEAD Study

J. M. Jakicic, S. A. Jaramillo, A. Balasubramanyam, B. Bancroft, J. M. Curtis, A. Mathews, M. Pereira, J. G. Regensteiner, P. M. Ribisl

Research output: Contribution to journal › Article › peer-review

110 Scopus citations

Abstract

Objective: To examine the effect of an intensive lifestyle weight loss intervention (ILI) compared to diabetes support and education (DSE) on changes in fitness and physical activity in the Look AHEAD trial. Design: Randomized clinical trial to compare a lifestyle intervention for weight loss with a DSE condition in individuals with type 2 diabetes. Subjects: Data from 4376 overweight or obese adults with type 2 diabetes (age=58.7±6.8 years, body mass index (BMI)=35.8±5.8 kg/m²) who completed 1 year of the Look AHEAD trial and had available fitness data were analyzed. Intervention: Subjects were randomly assigned to DSE or ILI. DSE received standard care plus three education sessions over the 1-year period. ILI included individual and group contact throughout the year, restriction in energy intake and 175 min per week of prescribed physical activity. Measurements: Fitness was assessed using a submaximal graded exercise test. Physical activity was assessed by questionnaire in a subset of 2221 subjects. Results: Change in fitness was statistically greater in ILI vs DSE after adjustment for baseline fitness (20.9 vs 5.7%; P<0.0001). Multivariate analysis showed that change in fitness was greater in overweight vs obese Class II and III (P<0.05). Physical activity increased by 892±1694 kcal per week in ILI vs 108±1254 kcal per week in DSE (P<0.01). Changes in fitness (r=0.41) and physical activity (r=0.42) were significantly correlated with weight loss (P<0.0001). Conclusions: The ILI was effective in increasing physical activity and improving cardiorespiratory fitness in overweight and obese individuals with type 2 diabetes. This effect may add to weight loss in improving metabolic control in patients in lifestyle intervention programs.

Original language	English (US)
Pages (from-to)	305-316
Number of pages	12
Journal	International Journal of Obesity
Volume	33
Issue number	3
DOIs	https://doi.org/10.1038/ijo.2008.280
State	Published - Mar 2009

Bibliographical note

Funding Information:
Additional support was received from The Johns Hopkins Medical Institutions Bayview General Clinical Research Center (M01RR02719); the Massachusetts General Hospital Mallinckrodt General Clinical Research Center (M01RR01066); the University of Colorado Health Sciences Center General Clinical Research Center (M01RR00051) and Clinical Nutrition Research Unit (P30 DK48520); the University of Tennessee at Memphis General Clinical Research Center (M01RR0021140); the University of Pittsburgh General Clinical Research Center (M01RR000056 44) and NIH grant (DK 046204); and the University of Washington/VA Puget Sound Health Care System Medical Research Service, Department of Veterans Affairs; Frederic C Bartter General Clinical Research Center (M01RR01346).

Funding Information:
This study was supported by the Department of Health and Human Services through the following cooperative agreements from the National Institutes of Health: DK57136, DK57149, DK56990, DK57177, DK57171, DK57151, DK57182, DK57131, DK57002, DK57078, DK57154, DK57178, DK57219, DK57008, DK57135 and DK56992. The following federal agencies have contributed support: National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; National Institute of Nursing Research; National Center on Minority Health and Health Disparities; Office of Research on Women’s Health and the Centers for Disease Control and Prevention. This research was supported in part by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases.

Keywords

Diabetes
Exercise
Fitness
Physical activity

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/ijo.2008.280

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Jakicic, J. M., Jaramillo, S. A., Balasubramanyam, A., Bancroft, B., Curtis, J. M., Mathews, A., Pereira, M., Regensteiner, J. G., & Ribisl, P. M. (2009). Effect of a lifestyle intervention on change in cardiorespiratory fitness in adults with type 2 diabetes: Results from the Look AHEAD Study. International Journal of Obesity, 33(3), 305-316. https://doi.org/10.1038/ijo.2008.280

Jakicic, JM, Jaramillo, SA, Balasubramanyam, A, Bancroft, B, Curtis, JM, Mathews, A, Pereira, M, Regensteiner, JG & Ribisl, PM 2009, 'Effect of a lifestyle intervention on change in cardiorespiratory fitness in adults with type 2 diabetes: Results from the Look AHEAD Study', International Journal of Obesity, vol. 33, no. 3, pp. 305-316. https://doi.org/10.1038/ijo.2008.280

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abstract = "Objective: To examine the effect of an intensive lifestyle weight loss intervention (ILI) compared to diabetes support and education (DSE) on changes in fitness and physical activity in the Look AHEAD trial. Design: Randomized clinical trial to compare a lifestyle intervention for weight loss with a DSE condition in individuals with type 2 diabetes. Subjects: Data from 4376 overweight or obese adults with type 2 diabetes (age=58.7±6.8 years, body mass index (BMI)=35.8±5.8 kg/m2) who completed 1 year of the Look AHEAD trial and had available fitness data were analyzed. Intervention: Subjects were randomly assigned to DSE or ILI. DSE received standard care plus three education sessions over the 1-year period. ILI included individual and group contact throughout the year, restriction in energy intake and 175 min per week of prescribed physical activity. Measurements: Fitness was assessed using a submaximal graded exercise test. Physical activity was assessed by questionnaire in a subset of 2221 subjects. Results: Change in fitness was statistically greater in ILI vs DSE after adjustment for baseline fitness (20.9 vs 5.7%; P<0.0001). Multivariate analysis showed that change in fitness was greater in overweight vs obese Class II and III (P<0.05). Physical activity increased by 892±1694 kcal per week in ILI vs 108±1254 kcal per week in DSE (P<0.01). Changes in fitness (r=0.41) and physical activity (r=0.42) were significantly correlated with weight loss (P<0.0001). Conclusions: The ILI was effective in increasing physical activity and improving cardiorespiratory fitness in overweight and obese individuals with type 2 diabetes. This effect may add to weight loss in improving metabolic control in patients in lifestyle intervention programs.",

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author = "Jakicic, {J. M.} and Jaramillo, {S. A.} and A. Balasubramanyam and B. Bancroft and Curtis, {J. M.} and A. Mathews and M. Pereira and Regensteiner, {J. G.} and Ribisl, {P. M.}",

note = "Funding Information: Additional support was received from The Johns Hopkins Medical Institutions Bayview General Clinical Research Center (M01RR02719); the Massachusetts General Hospital Mallinckrodt General Clinical Research Center (M01RR01066); the University of Colorado Health Sciences Center General Clinical Research Center (M01RR00051) and Clinical Nutrition Research Unit (P30 DK48520); the University of Tennessee at Memphis General Clinical Research Center (M01RR0021140); the University of Pittsburgh General Clinical Research Center (M01RR000056 44) and NIH grant (DK 046204); and the University of Washington/VA Puget Sound Health Care System Medical Research Service, Department of Veterans Affairs; Frederic C Bartter General Clinical Research Center (M01RR01346). Funding Information: This study was supported by the Department of Health and Human Services through the following cooperative agreements from the National Institutes of Health: DK57136, DK57149, DK56990, DK57177, DK57171, DK57151, DK57182, DK57131, DK57002, DK57078, DK57154, DK57178, DK57219, DK57008, DK57135 and DK56992. The following federal agencies have contributed support: National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; National Institute of Nursing Research; National Center on Minority Health and Health Disparities; Office of Research on Women{\textquoteright}s Health and the Centers for Disease Control and Prevention. This research was supported in part by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases.",

year = "2009",

month = mar,

doi = "10.1038/ijo.2008.280",

language = "English (US)",

volume = "33",

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T1 - Effect of a lifestyle intervention on change in cardiorespiratory fitness in adults with type 2 diabetes

T2 - Results from the Look AHEAD Study

AU - Jakicic, J. M.

AU - Jaramillo, S. A.

AU - Balasubramanyam, A.

AU - Bancroft, B.

AU - Curtis, J. M.

AU - Mathews, A.

AU - Pereira, M.

AU - Regensteiner, J. G.

AU - Ribisl, P. M.

N1 - Funding Information: Additional support was received from The Johns Hopkins Medical Institutions Bayview General Clinical Research Center (M01RR02719); the Massachusetts General Hospital Mallinckrodt General Clinical Research Center (M01RR01066); the University of Colorado Health Sciences Center General Clinical Research Center (M01RR00051) and Clinical Nutrition Research Unit (P30 DK48520); the University of Tennessee at Memphis General Clinical Research Center (M01RR0021140); the University of Pittsburgh General Clinical Research Center (M01RR000056 44) and NIH grant (DK 046204); and the University of Washington/VA Puget Sound Health Care System Medical Research Service, Department of Veterans Affairs; Frederic C Bartter General Clinical Research Center (M01RR01346). Funding Information: This study was supported by the Department of Health and Human Services through the following cooperative agreements from the National Institutes of Health: DK57136, DK57149, DK56990, DK57177, DK57171, DK57151, DK57182, DK57131, DK57002, DK57078, DK57154, DK57178, DK57219, DK57008, DK57135 and DK56992. The following federal agencies have contributed support: National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; National Institute of Nursing Research; National Center on Minority Health and Health Disparities; Office of Research on Women’s Health and the Centers for Disease Control and Prevention. This research was supported in part by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases.

PY - 2009/3

Y1 - 2009/3

N2 - Objective: To examine the effect of an intensive lifestyle weight loss intervention (ILI) compared to diabetes support and education (DSE) on changes in fitness and physical activity in the Look AHEAD trial. Design: Randomized clinical trial to compare a lifestyle intervention for weight loss with a DSE condition in individuals with type 2 diabetes. Subjects: Data from 4376 overweight or obese adults with type 2 diabetes (age=58.7±6.8 years, body mass index (BMI)=35.8±5.8 kg/m2) who completed 1 year of the Look AHEAD trial and had available fitness data were analyzed. Intervention: Subjects were randomly assigned to DSE or ILI. DSE received standard care plus three education sessions over the 1-year period. ILI included individual and group contact throughout the year, restriction in energy intake and 175 min per week of prescribed physical activity. Measurements: Fitness was assessed using a submaximal graded exercise test. Physical activity was assessed by questionnaire in a subset of 2221 subjects. Results: Change in fitness was statistically greater in ILI vs DSE after adjustment for baseline fitness (20.9 vs 5.7%; P<0.0001). Multivariate analysis showed that change in fitness was greater in overweight vs obese Class II and III (P<0.05). Physical activity increased by 892±1694 kcal per week in ILI vs 108±1254 kcal per week in DSE (P<0.01). Changes in fitness (r=0.41) and physical activity (r=0.42) were significantly correlated with weight loss (P<0.0001). Conclusions: The ILI was effective in increasing physical activity and improving cardiorespiratory fitness in overweight and obese individuals with type 2 diabetes. This effect may add to weight loss in improving metabolic control in patients in lifestyle intervention programs.

AB - Objective: To examine the effect of an intensive lifestyle weight loss intervention (ILI) compared to diabetes support and education (DSE) on changes in fitness and physical activity in the Look AHEAD trial. Design: Randomized clinical trial to compare a lifestyle intervention for weight loss with a DSE condition in individuals with type 2 diabetes. Subjects: Data from 4376 overweight or obese adults with type 2 diabetes (age=58.7±6.8 years, body mass index (BMI)=35.8±5.8 kg/m2) who completed 1 year of the Look AHEAD trial and had available fitness data were analyzed. Intervention: Subjects were randomly assigned to DSE or ILI. DSE received standard care plus three education sessions over the 1-year period. ILI included individual and group contact throughout the year, restriction in energy intake and 175 min per week of prescribed physical activity. Measurements: Fitness was assessed using a submaximal graded exercise test. Physical activity was assessed by questionnaire in a subset of 2221 subjects. Results: Change in fitness was statistically greater in ILI vs DSE after adjustment for baseline fitness (20.9 vs 5.7%; P<0.0001). Multivariate analysis showed that change in fitness was greater in overweight vs obese Class II and III (P<0.05). Physical activity increased by 892±1694 kcal per week in ILI vs 108±1254 kcal per week in DSE (P<0.01). Changes in fitness (r=0.41) and physical activity (r=0.42) were significantly correlated with weight loss (P<0.0001). Conclusions: The ILI was effective in increasing physical activity and improving cardiorespiratory fitness in overweight and obese individuals with type 2 diabetes. This effect may add to weight loss in improving metabolic control in patients in lifestyle intervention programs.

KW - Diabetes

KW - Exercise

KW - Fitness

KW - Physical activity

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Effect of a lifestyle intervention on change in cardiorespiratory fitness in adults with type 2 diabetes: Results from the Look AHEAD Study

Abstract

Bibliographical note

Keywords

UN SDGs

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