Abstract
The effect of 6-hydroxydopamine on in vitro and in vivo cerebral protein synthesis was studied in rats. Male rats receiving 200 μg of 6-hydroxydopamine intracisternally daily for three injections showed a significant decrease in incorporating activity of 14C-leucine into brain microsomal and synaptosomal proteins over that of control animals in vitro. Experiments with intracisternally injected 14C-leucine also showed a decreased incorporation of labeled amino acid in 6-hydroxydopamine treated animals in mitochondria, crude nuclei, "noncholinergic" synaptosome and myelin fraction, while no change was demonstrated in the other fractions. The degeneration of adrenergic nerve endings by 6-hydroxydopamine may be related to its inhibitory action on brain protein synthesis.
Original language | English (US) |
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Pages (from-to) | 1171-1180 |
Number of pages | 10 |
Journal | Life Sciences |
Volume | 10 |
Issue number | 20 PART 1 |
DOIs | |
State | Published - Oct 15 1971 |