Effect of 40-cm segment umbilical cord milking on hemoglobin and serum ferritin at 6 months of age in full-term infants of anemic and non-anemic mothers

R. Bora, S. S. Akhtar, A. Venkatasubramaniam, Julian Wolfson, Raghu Rao

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17 Citations (Scopus)

Abstract

Objective: To assess the effect of early clamping and milking of a 40-cm umbilical cord LUCM (long umbilical cord and milking) on hemoglobin (Hb) and serum ferritin concentrations at 6 months of age and to evaluate whether the effect is different in infants of anemic and non-anemic mothers. Study design: Eligible term-infants of anemic (maternal Hb<11.0 g dl-1) and non-anemic mothers (Hb ≥11.0 g dl-1) were randomized to LUCM or control groups (N=100 each). In the LUCM group, the umbilical cord was clamped at 40-cm length and milked. The control group had the cord clamped at 5 cm and not milked. Neonatal morbidities until discharge and Hb and serum ferritin at 6 months of age were compared. Effects in infants of anemic and non-anemic mothers were compared. Result: Compared with infants of non-anemic mothers, cord Hb was similar (14.50±1.90 g dl-1 vs 14.67±1.73 g dl-1), but cord ferritin lower (85.8±55.4 ng ml-1 vs 119.4±58.5 ng ml-1, P<0.01) in infants of anemic mothers. Mean Hb concentration at 6 months was 9.60±1.42 g dl-1 in the LUCM group and 9.07±1.10 g dl-1 in the control group (P=0.004). Mean serum-ferritin concentration at 6 months was 113.9±43.8 ng ml-1 in the LUCM group and 70.8±39.5 ng/ml in the control group (P<0.001). The effectiveness of LUCM did not vary with the maternal anemia status. Conclusion: Keeping the umbilical cord long and milking may be an effective method for improving Hb and iron stores at 6 months of age in term-infants.

Original languageEnglish (US)
Pages (from-to)832-836
Number of pages5
JournalJournal of Perinatology
Volume35
Issue number10
DOIs
StatePublished - Oct 1 2015

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Umbilical Cord
Ferritins
Hemoglobins
Mothers
Serum
Control Groups
Constriction
Anemia
Iron
Morbidity

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Effect of 40-cm segment umbilical cord milking on hemoglobin and serum ferritin at 6 months of age in full-term infants of anemic and non-anemic mothers. / Bora, R.; Akhtar, S. S.; Venkatasubramaniam, A.; Wolfson, Julian; Rao, Raghu.

In: Journal of Perinatology, Vol. 35, No. 10, 01.10.2015, p. 832-836.

Research output: Contribution to journalArticle

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abstract = "Objective: To assess the effect of early clamping and milking of a 40-cm umbilical cord LUCM (long umbilical cord and milking) on hemoglobin (Hb) and serum ferritin concentrations at 6 months of age and to evaluate whether the effect is different in infants of anemic and non-anemic mothers. Study design: Eligible term-infants of anemic (maternal Hb<11.0 g dl-1) and non-anemic mothers (Hb ≥11.0 g dl-1) were randomized to LUCM or control groups (N=100 each). In the LUCM group, the umbilical cord was clamped at 40-cm length and milked. The control group had the cord clamped at 5 cm and not milked. Neonatal morbidities until discharge and Hb and serum ferritin at 6 months of age were compared. Effects in infants of anemic and non-anemic mothers were compared. Result: Compared with infants of non-anemic mothers, cord Hb was similar (14.50±1.90 g dl-1 vs 14.67±1.73 g dl-1), but cord ferritin lower (85.8±55.4 ng ml-1 vs 119.4±58.5 ng ml-1, P<0.01) in infants of anemic mothers. Mean Hb concentration at 6 months was 9.60±1.42 g dl-1 in the LUCM group and 9.07±1.10 g dl-1 in the control group (P=0.004). Mean serum-ferritin concentration at 6 months was 113.9±43.8 ng ml-1 in the LUCM group and 70.8±39.5 ng/ml in the control group (P<0.001). The effectiveness of LUCM did not vary with the maternal anemia status. Conclusion: Keeping the umbilical cord long and milking may be an effective method for improving Hb and iron stores at 6 months of age in term-infants.",
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AU - Wolfson, Julian

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AB - Objective: To assess the effect of early clamping and milking of a 40-cm umbilical cord LUCM (long umbilical cord and milking) on hemoglobin (Hb) and serum ferritin concentrations at 6 months of age and to evaluate whether the effect is different in infants of anemic and non-anemic mothers. Study design: Eligible term-infants of anemic (maternal Hb<11.0 g dl-1) and non-anemic mothers (Hb ≥11.0 g dl-1) were randomized to LUCM or control groups (N=100 each). In the LUCM group, the umbilical cord was clamped at 40-cm length and milked. The control group had the cord clamped at 5 cm and not milked. Neonatal morbidities until discharge and Hb and serum ferritin at 6 months of age were compared. Effects in infants of anemic and non-anemic mothers were compared. Result: Compared with infants of non-anemic mothers, cord Hb was similar (14.50±1.90 g dl-1 vs 14.67±1.73 g dl-1), but cord ferritin lower (85.8±55.4 ng ml-1 vs 119.4±58.5 ng ml-1, P<0.01) in infants of anemic mothers. Mean Hb concentration at 6 months was 9.60±1.42 g dl-1 in the LUCM group and 9.07±1.10 g dl-1 in the control group (P=0.004). Mean serum-ferritin concentration at 6 months was 113.9±43.8 ng ml-1 in the LUCM group and 70.8±39.5 ng/ml in the control group (P<0.001). The effectiveness of LUCM did not vary with the maternal anemia status. Conclusion: Keeping the umbilical cord long and milking may be an effective method for improving Hb and iron stores at 6 months of age in term-infants.

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