The addition of 3,3-dimethylacrylic acid, a side-chain precursor of meilingmycin's main component MB1, greatly stimulated the production of MB1 and its proportion in meilingmycin complex during fermentation. In this way, the higher production and the better component composition could be achieved. In addition, the feeding mode and the feeding time as well as the feeding concentration of the side-chain precursor were optimized and discussed. The results indicated that the highest MB1 production was increased by 43% and its proportion reached up to 52.7% when the supplement of 6mmol/L side-chain at 0h of cultivation was conducted.
|Original language||English (US)|
|Number of pages||5|
|Journal||Chinese Journal of Antibiotics|
|State||Published - Jan 1 2005|
- 3,3-Dimethylacrylic acid
- Side-chain precursor