Effect of 3,3-dimethylacrylic acid on the biosynthesis of meilingmycin

Ping Wang, Ying Ping Zhuang, Ju Chu, Si Liang Zhang

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The addition of 3,3-dimethylacrylic acid, a side-chain precursor of meilingmycin's main component MB1, greatly stimulated the production of MB1 and its proportion in meilingmycin complex during fermentation. In this way, the higher production and the better component composition could be achieved. In addition, the feeding mode and the feeding time as well as the feeding concentration of the side-chain precursor were optimized and discussed. The results indicated that the highest MB1 production was increased by 43% and its proportion reached up to 52.7% when the supplement of 6mmol/L side-chain at 0h of cultivation was conducted.

Original languageEnglish (US)
Pages (from-to)581-585
Number of pages5
JournalChinese Journal of Antibiotics
Issue number10
StatePublished - 2005


  • 3,3-Dimethylacrylic acid
  • Meilingmycin
  • Side-chain precursor


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