Abstract
BACKGROUND: The CYP2B6-G516T polymorphism has been shown to alter plasma efavirenz (EFV) concentrations in adults. The impact of CYP2B6-G516T polymorphisms on EFV concentrations may be different in children because of differences in liver maturation and drug dosage. METHODS: The CYP2B6-G516T polymorphisms were analyzed in 71 HIV-1-infected children receiving highly active antiretroviral therapy (HAART) containing EFV for ≥6 months. EFV pharmacokinetics, toxicity profiles, and viral resistance data were also evaluated. RESULTS: The median oral clearance (CL/F) rate was significantly lower in children with the CYP2B6-516-T/T genotype (3.0 L/h/m, n = 13) than in children with the G/T genotype (5.7 L/h/m, n = 30; P = 0.02) or the G/G genotype (7.0 L/h/m, n = 31; P = 0.003). In children with the CYP2B6-516-G/G genotype, which is associated with higher expression of hepatic CYP2B6, the clearance rate was significantly higher in younger children (<5 years of age) than in older children (≥5 years of age) (9.7 L/h/m vs. 6.6 L/h/m; P = 0.03). No association was found between CYP2B6-G516T polymorphisms and virologic or immunologic responses, toxicity, or the development of viral resistance against EFV. CONCLUSIONS: CYP2B6-G516T polymorphisms significantly affect the CL/F rate of EFV in children. Changes in hepatic enzyme activity by age may need to be considered when evaluating the impact of genetic variants on antiretroviral pharmacokinetics in children.
Original language | English (US) |
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Pages (from-to) | 280-285 |
Number of pages | 6 |
Journal | Journal of Acquired Immune Deficiency Syndromes |
Volume | 45 |
Issue number | 3 |
DOIs | |
State | Published - Jul 2007 |
Keywords
- Age
- CYP2B6
- Children
- Efavirenz
- Pharmacogenomics
- Resistance