EEG source imaging: Correlating source locations and extents with electrocorticography and surgical resections in epilepsy patients

Lei Ding, Christopher Wilke, Bobby Xu, Xiaoliang Xu, Wim Van Drongelen, Michael Kohrman, Bin He

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

It is desirable to estimate epileptogenic zones with both location and extent information from noninvasive EEG. In the present study, the authors use a subspace source localization method (FINE), combined with a local thresholding technique, to achieve such tasks. The performance of this method was evaluated in interictal spikes from three pediatric patients with medically intractable partial epilepsy. The thresholded subspace correlation, which is obtained from FINE scanning, is a favorable marker, which implies the extents of current sources associated with epileptic activities. The findings were validated by comparing the results with invasive electrocorticographic (ECoG) recordings of interictal spike activity. The surgical resections in these three patients correlated well with the epileptogenic zones identified from both EEG sources and ECoG potential distributions. The value of the proposed noninvasive technique for estimating epileptiform activity was supported by satisfactory surgery outcomes.

Original languageEnglish (US)
Pages (from-to)130-136
Number of pages7
JournalJournal of Clinical Neurophysiology
Volume24
Issue number2
DOIs
StatePublished - Apr 2007

Keywords

  • ECoG
  • EEG
  • Epilepsy
  • Extent
  • FINE
  • Interictal
  • MRI
  • Source localization
  • Surgical outcome

Fingerprint Dive into the research topics of 'EEG source imaging: Correlating source locations and extents with electrocorticography and surgical resections in epilepsy patients'. Together they form a unique fingerprint.

Cite this