Economically viable efficient synthesis of (±)-methysticin: A component in kava potentially responsible for its cancer chemopreventive activity

Ahmad Ali Shaik; Jonathan Tan; Junxuan Lü; Chengguo Xing

doi:10.3998/ark.5550190.0013.813

Economically viable efficient synthesis of (±)-methysticin: A component in kava potentially responsible for its cancer chemopreventive activity

Ahmad Ali Shaik, Jonathan Tan, Junxuan Lü, Chengguo Xing

Medicinal Chemistry

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

A highly efficient and green synthesis of (±)-methysticin was developed from inexpensive piperonal, requiring two extraction procedures and one chromatographic purification in the final step with 51% overall yield. This new method is superior compared to known literature procedures and is highly reproducible and scalable up to gram scale.

Original language	English (US)
Pages (from-to)	137-145
Number of pages	9
Journal	Arkivoc
Volume	2012
Issue number	8
DOIs	https://doi.org/10.3998/ark.5550190.0013.813
State	Published - Jun 29 2012

Bibliographical note

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Copyright 2018 Elsevier B.V., All rights reserved.

Keywords

Aldol condensation
Kava
Kavalactones
Lactonization
Methysticin
NF-?B inhibitory activity

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3998/ark.5550190.0013.813

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abstract = "A highly efficient and green synthesis of (±)-methysticin was developed from inexpensive piperonal, requiring two extraction procedures and one chromatographic purification in the final step with 51% overall yield. This new method is superior compared to known literature procedures and is highly reproducible and scalable up to gram scale.",

keywords = "Aldol condensation, Kava, Kavalactones, Lactonization, Methysticin, NF-?B inhibitory activity",

author = "{Ali Shaik}, Ahmad and Jonathan Tan and Junxuan L{\"u} and Chengguo Xing",

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T2 - A component in kava potentially responsible for its cancer chemopreventive activity

AU - Ali Shaik, Ahmad

AU - Tan, Jonathan

AU - Lü, Junxuan

AU - Xing, Chengguo

PY - 2012/6/29

Y1 - 2012/6/29

N2 - A highly efficient and green synthesis of (±)-methysticin was developed from inexpensive piperonal, requiring two extraction procedures and one chromatographic purification in the final step with 51% overall yield. This new method is superior compared to known literature procedures and is highly reproducible and scalable up to gram scale.

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KW - Aldol condensation

KW - Kava

KW - Kavalactones

KW - Lactonization

KW - Methysticin

KW - NF-?B inhibitory activity

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Economically viable efficient synthesis of (±)-methysticin: A component in kava potentially responsible for its cancer chemopreventive activity

Abstract

Bibliographical note

Keywords

UN SDGs

Publisher link

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