Echinacea purpurea Root Extract Increases Tumor Necrosis Factor Production by Concanavalin A-Activated Murine Splenocytes

Mikaela P. Cadiz, Mackenzie R. Schara, Bailey H. Kemp, Rachel M.Gibbons Johnson

    Research output: Contribution to journalArticlepeer-review

    1 Scopus citations

    Abstract

    Echinacea purpurea is a common herbal remedy used to treat a variety of illnesses, though its health benefits and effects on the immune system have not been fully elucidated. In this study, we investigated the effect of E. purpurea root extract on the survival of concanavalin A (ConA)-Activated murine splenocytes and the production of the cytokines interferon-gamma (IFN-γ), interleukin-2 (IL-2), and tumor necrosis factor (TNF) by these cells. We found that E. purpurea root extract did not affect splenocyte survival or IL-2 production and increased IFN-γcytokine levels only modestly. However, TNF cytokine production by ConA-Activated splenocytes increased in response to E. purpurea root extract treatment in a dose-dependent manner, suggesting that E. purpurea root extract does have immunomodulatory effects.

    Original languageEnglish (US)
    Pages (from-to)1146-1150
    Number of pages5
    JournalJournal of Medicinal Food
    Volume22
    Issue number11
    DOIs
    StatePublished - Nov 2019

    Bibliographical note

    Funding Information:
    This work was supported by the University of Minnesota Undergraduate Research Opportunity Program and the Office of the Vice President for Research of the University of Minnesota (UMM Faculty Enhancement Research Fund).

    Publisher Copyright:
    © Copyright 2019, Mary Ann Liebert, Inc., publishers, and Korean Society of Food Science and Nutrition 2019.

    Keywords

    • cytokines
    • herbal supplement
    • immunomodulation

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