Ecdysone control of developmental transitions: Lessons from drosophila research

Naoki Yamanaka, Kim F. Rewitz, Michael B O'Connor

Research output: Contribution to journalReview articlepeer-review

399 Scopus citations


The steroid hormone ecdysone is the central regulator of insect developmental transitions. Recent new advances in our understanding of ecdysone action have relied heavily on the application of Drosophila melanogaster molecular genetic tools to study insect metamorphosis. In this review, we focus on three major aspects of Drosophila ecdysone biology: (a) factors that regulate the timing of ecdysone release, (b) molecular basis of stage-and tissue-specific responses to ecdysone, and (c) feedback regulation and coordination of ecdysone signaling.

Original languageEnglish (US)
Pages (from-to)497-516
Number of pages20
JournalAnnual review of entomology
StatePublished - Jan 7 2013


  • Ashburner model
  • critical weight
  • developmental timing
  • metamorphosis
  • prothoracicotropic hormone


Dive into the research topics of 'Ecdysone control of developmental transitions: Lessons from drosophila research'. Together they form a unique fingerprint.

Cite this