Early redistribution of Thallium-201 after temporary ischemia

J. S. Schwartz, R. Ponto, P. Carlyle, L. Forstrom, Jay N Cohn

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

To define the time course of redistribution of thallium-201 (201TI), ischemia was induced in seven pigs by temporary occlusion of the circumflex coronary artery. After 1 1/2 min of occlusion 201TI and labeled microspheres were injected into the left atrium. Flow was re-established 4 min after occlusion. Prior to reflow, the relative activities of 201TI and microspheres in the ischemic area were similar, but as early as 5 min after reflow the relative 201TI activity was considerably higher than the relative microsphere activity and from 15 to 105 min after reflow, relative 201TI activity (average 69% of that in normal myocardium) continued to be higher than relative microsphere activity (average 6% of normal). Myocardial arteriovenous differences for 201TI were followed sequentially after 201TI injection in normal dogs and in dogs with temporary coronary occlusions. The results suggested both loss of 201TI from normal myocardium beginning 10 min after 201TI injection and increased extraction of 201TI from the blood pool immediately after release of a transient occlusion. Redistribution of 201Tl therefore begins very soon after relief of myocardial ischemia and even a short delay in initiating myocardial imaging may decrease the sensitivity of the technique for detecting transient ischemia.

Original languageEnglish (US)
Pages (from-to)332-335
Number of pages4
JournalUnknown Journal
Volume57
Issue number2
DOIs
StatePublished - Jan 1 1978

Fingerprint

Thallium
Microspheres
Ischemia
Myocardium
Dogs
Injections
Coronary Occlusion
Heart Atria
Myocardial Ischemia
Coronary Vessels
Blood
Swine
Imaging techniques

Cite this

Early redistribution of Thallium-201 after temporary ischemia. / Schwartz, J. S.; Ponto, R.; Carlyle, P.; Forstrom, L.; Cohn, Jay N.

In: Unknown Journal, Vol. 57, No. 2, 01.01.1978, p. 332-335.

Research output: Contribution to journalArticle

Schwartz, JS, Ponto, R, Carlyle, P, Forstrom, L & Cohn, JN 1978, 'Early redistribution of Thallium-201 after temporary ischemia', Unknown Journal, vol. 57, no. 2, pp. 332-335. https://doi.org/10.1161/01.CIR.57.2.332
Schwartz, J. S. ; Ponto, R. ; Carlyle, P. ; Forstrom, L. ; Cohn, Jay N. / Early redistribution of Thallium-201 after temporary ischemia. In: Unknown Journal. 1978 ; Vol. 57, No. 2. pp. 332-335.
@article{90a344208f594ba29b8effc699557810,
title = "Early redistribution of Thallium-201 after temporary ischemia",
abstract = "To define the time course of redistribution of thallium-201 (201TI), ischemia was induced in seven pigs by temporary occlusion of the circumflex coronary artery. After 1 1/2 min of occlusion 201TI and labeled microspheres were injected into the left atrium. Flow was re-established 4 min after occlusion. Prior to reflow, the relative activities of 201TI and microspheres in the ischemic area were similar, but as early as 5 min after reflow the relative 201TI activity was considerably higher than the relative microsphere activity and from 15 to 105 min after reflow, relative 201TI activity (average 69{\%} of that in normal myocardium) continued to be higher than relative microsphere activity (average 6{\%} of normal). Myocardial arteriovenous differences for 201TI were followed sequentially after 201TI injection in normal dogs and in dogs with temporary coronary occlusions. The results suggested both loss of 201TI from normal myocardium beginning 10 min after 201TI injection and increased extraction of 201TI from the blood pool immediately after release of a transient occlusion. Redistribution of 201Tl therefore begins very soon after relief of myocardial ischemia and even a short delay in initiating myocardial imaging may decrease the sensitivity of the technique for detecting transient ischemia.",
author = "Schwartz, {J. S.} and R. Ponto and P. Carlyle and L. Forstrom and Cohn, {Jay N}",
year = "1978",
month = "1",
day = "1",
doi = "10.1161/01.CIR.57.2.332",
language = "English (US)",
volume = "57",
pages = "332--335",
journal = "Journal of Fluid Mechanics",
issn = "0022-1120",
publisher = "Cambridge University Press",
number = "2",

}

TY - JOUR

T1 - Early redistribution of Thallium-201 after temporary ischemia

AU - Schwartz, J. S.

AU - Ponto, R.

AU - Carlyle, P.

AU - Forstrom, L.

AU - Cohn, Jay N

PY - 1978/1/1

Y1 - 1978/1/1

N2 - To define the time course of redistribution of thallium-201 (201TI), ischemia was induced in seven pigs by temporary occlusion of the circumflex coronary artery. After 1 1/2 min of occlusion 201TI and labeled microspheres were injected into the left atrium. Flow was re-established 4 min after occlusion. Prior to reflow, the relative activities of 201TI and microspheres in the ischemic area were similar, but as early as 5 min after reflow the relative 201TI activity was considerably higher than the relative microsphere activity and from 15 to 105 min after reflow, relative 201TI activity (average 69% of that in normal myocardium) continued to be higher than relative microsphere activity (average 6% of normal). Myocardial arteriovenous differences for 201TI were followed sequentially after 201TI injection in normal dogs and in dogs with temporary coronary occlusions. The results suggested both loss of 201TI from normal myocardium beginning 10 min after 201TI injection and increased extraction of 201TI from the blood pool immediately after release of a transient occlusion. Redistribution of 201Tl therefore begins very soon after relief of myocardial ischemia and even a short delay in initiating myocardial imaging may decrease the sensitivity of the technique for detecting transient ischemia.

AB - To define the time course of redistribution of thallium-201 (201TI), ischemia was induced in seven pigs by temporary occlusion of the circumflex coronary artery. After 1 1/2 min of occlusion 201TI and labeled microspheres were injected into the left atrium. Flow was re-established 4 min after occlusion. Prior to reflow, the relative activities of 201TI and microspheres in the ischemic area were similar, but as early as 5 min after reflow the relative 201TI activity was considerably higher than the relative microsphere activity and from 15 to 105 min after reflow, relative 201TI activity (average 69% of that in normal myocardium) continued to be higher than relative microsphere activity (average 6% of normal). Myocardial arteriovenous differences for 201TI were followed sequentially after 201TI injection in normal dogs and in dogs with temporary coronary occlusions. The results suggested both loss of 201TI from normal myocardium beginning 10 min after 201TI injection and increased extraction of 201TI from the blood pool immediately after release of a transient occlusion. Redistribution of 201Tl therefore begins very soon after relief of myocardial ischemia and even a short delay in initiating myocardial imaging may decrease the sensitivity of the technique for detecting transient ischemia.

UR - http://www.scopus.com/inward/record.url?scp=0017890582&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017890582&partnerID=8YFLogxK

U2 - 10.1161/01.CIR.57.2.332

DO - 10.1161/01.CIR.57.2.332

M3 - Article

C2 - 618622

AN - SCOPUS:0017890582

VL - 57

SP - 332

EP - 335

JO - Journal of Fluid Mechanics

JF - Journal of Fluid Mechanics

SN - 0022-1120

IS - 2

ER -