Early postnatal deprivation of active sleep with desipramine or zimeldine impairs later behavioural reactivity to auditory stimuli in rats

L. A. HILAKIVI, T. TAIRA, I. HILAKIVI

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

To examine the functional significance of early postnatal active sleep for the development of behavioural reactivity to auditory stimuli, rat pups were daily injected i.p. from the 7th to the 18th postnatal days with 5 mg kg‐1 (6.6 mmol 1‐1) desipramine or 25 mg kg‐1 (12.2 mmol 1‐1) zimeldine. Sleep‐wake behaviour was recorded with a static‐charge‐sensitive bed (SCSB) method. Both desipramine and zimeldine suppressed the percentage of active sleep relative to the total recording time throughout the treatment period. In addition, these drugs increased the percentage of quiet state and waking. At the age of 38 days the zimeldine‐treated rats showed more motor activity in the open field than the controls. At the age of 39 and 78 days all rat groups behaved similarly in the open field. Startle measures and motor activation, provoked by auditory stimulation, were determined by the SCSB method when the rats were 4 months of age. Auditory stimuli, consisting of a series of ten clicks, induced a greater number of startles as well as strong movement responses in the control rats than in the desipramine‐ or zimeldine‐treated rats. The number of small movement responses did not differ between the rat groups. These findings indicate that early postnatal active sleep and the monoaminergic systems regulating it may be important for the normal development of neuronal circuitry associated with later reactivity to auditory stimuli.

Original languageEnglish (US)
Pages (from-to)191-198
Number of pages8
JournalActa Physiologica Scandinavica
Volume132
Issue number2
DOIs
StatePublished - Feb 1988
Externally publishedYes

Keywords

  • active sleep
  • behavioural reactivity
  • desipramine
  • ontogeny
  • open‐field behaviour
  • rat
  • reactive depression
  • static‐charge‐sensitive bed
  • zimeldine

Fingerprint Dive into the research topics of 'Early postnatal deprivation of active sleep with desipramine or zimeldine impairs later behavioural reactivity to auditory stimuli in rats'. Together they form a unique fingerprint.

Cite this