Early outcomes of tricuspid valve replacement in young children

Heather L. Bartlett, Dianne L. Atkins, Trudy L. Burns, Kelly J. Engelkes, Sarah J. Powell, Christine B. Hills, James H Moller

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

BACKGROUND: Early outcomes after tricuspid valve replacement in young children are ill defined. The experience of the Pediatric Cardiac Care Consortium (45 centers, 1984 to 2002) was reviewed to evaluate the results of tricuspid valve replacement in children <6 years of age. METHODS AND RESULTS: Ninety-seven patients who underwent initial tricuspid valve replacement are included in the present analysis. The most frequent cardiac diagnoses were Ebstein's anomaly (40%), pulmonary atresia (11%), and tetralogy of Fallot (8%). Age at tricuspid valve replacement was 2.9±1.7 years (mean±SD). Mean patient weight was 12.7±6.1 kg. The major outcome was survival to discharge. Associations among age, diagnosis, valve type/size, and outcome were evaluated through the use of χ2 analysis and logistic regression model fitting approaches. Hospital mortality was 26% and was very high (64%) in patients <1 year of age. A large size-to-weight ratio was the strongest predictor of mortality based on multivariable analysis (P<0.001). Mortality was 54% for patients with a size-to-weight ratio >2.5. Other complications included heart block requiring a pacemaker (13%) and thrombosis (5%). Pacemaker implantation was associated with the use of a mechanical valve (23% versus 6% bioprosthetic valve; P=0.01) CONCLUSIONS: Tricuspid valve replacement in young children is associated with high mortality, especially in infants <1 year of age. Surgical options other than tricuspid valve replacement such as transplantation may need to be considered in infants.

Original languageEnglish (US)
Pages (from-to)319-325
Number of pages7
JournalCirculation
Volume115
Issue number3
DOIs
StatePublished - Jan 2007

Keywords

  • Heart defects, congenital
  • Pediatrics
  • Risk factors
  • Surgery
  • Tricuspid valve
  • Valves

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