Early life rhinovirus wheezing, allergic sensitization, and asthma risk at adolescence

Frederick J. Rubner, Daniel J. Jackson, Michael D. Evans, Ronald E. Gangnon, Christopher J. Tisler, Tressa E. Pappas, James E. Gern, Robert F. Lemanske

Research output: Contribution to journalArticlepeer-review

172 Scopus citations


Background Early life rhinovirus (RV) wheezing illnesses and aeroallergen sensitization increase the risk of asthma at school age. Whether these remain risk factors for the persistence of asthma out to adolescence is not established. Objective We sought to define the relationships among specific viral illnesses and the type and timing of aeroallergen sensitization with the persistence of asthma into adolescence. Methods A total of 217 children were followed prospectively from birth to age 13 years. The etiology and timing of viral wheezing illnesses during the first 3 years of life were assessed along with patterns of allergen sensitization. The associations between viral wheezing illnesses, presence and pattern of aeroallergen sensitization, and asthma diagnosis at age 13 years were evaluated. Results When adjusted for all viral etiologies, wheezing with RV (odds ratio = 3.3; 95% CI, 1.5-7.1), but not respiratory syncytial virus (odds ratio = 1.0; 95% CI, 0.4-2.3), was associated with asthma at age 13 years. Age of aeroallergen sensitization also influenced asthma risk; 65% of children sensitized by age 1 year had asthma at age 13 years, compared with 40% of children not sensitized at age 1 year but sensitized by age 5 years, and 17% of children not sensitized at age 5 years. Early life aeroallergen sensitization and RV wheezing had additive effects on asthma risk at adolescence. Conclusions In a high-risk birth cohort, the persistence of asthma at age 13 years was most strongly associated with outpatient wheezing illnesses with RV and aeroallergen sensitization in early life.

Original languageEnglish (US)
Pages (from-to)501-507
Number of pages7
JournalJournal of Allergy and Clinical Immunology
Issue number2
StatePublished - Feb 1 2017
Externally publishedYes

Bibliographical note

Funding Information:
This study was supported by the National Institutes of Health, National Heart, Lung, and Blood Institute (grant no. PO1 HL70381) and the National Center for Advancing Translational Sciences (grant no. UL1TR000427).

Publisher Copyright:
© 2016 American Academy of Allergy, Asthma & Immunology


  • Rhinovirus
  • allergic sensitization
  • asthma
  • respiratory syncytial virus


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