TY - JOUR
T1 - Early detection of pancreatic cancer
T2 - Current state and future opportunities
AU - Trikudanathan, Guru
AU - Lou, Emil
AU - Maitra, Anirban
AU - Majumder, Shounak
N1 - Publisher Copyright:
Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2021/9/1
Y1 - 2021/9/1
N2 - Purpose of reviewPancreatic ductal adenocarcinoma (PDAC) is third leading cause of cancer death in the United States, a lethal disease with no screening strategy. Although diagnosis at an early stage is associated with improved survival, clinical detection of PDAC is typically at an advanced symptomatic stage when best in class therapies have limited impact on survival.Recent findingsIn recent years this status quo has been challenged by the identification of novel risk factors, molecular markers of early-stage disease and innovations in pancreatic imaging. There is now expert consensus that screening may be pursued in a cohort of individuals with increased likelihood of developing PDAC based on genetic and familial risk.SummaryThe current review summarizes the known risk factors of PDAC, current knowledge and recent observations pertinent to early detection of PDAC in these risk groups and outlines future approaches that will potentially advance the field.
AB - Purpose of reviewPancreatic ductal adenocarcinoma (PDAC) is third leading cause of cancer death in the United States, a lethal disease with no screening strategy. Although diagnosis at an early stage is associated with improved survival, clinical detection of PDAC is typically at an advanced symptomatic stage when best in class therapies have limited impact on survival.Recent findingsIn recent years this status quo has been challenged by the identification of novel risk factors, molecular markers of early-stage disease and innovations in pancreatic imaging. There is now expert consensus that screening may be pursued in a cohort of individuals with increased likelihood of developing PDAC based on genetic and familial risk.SummaryThe current review summarizes the known risk factors of PDAC, current knowledge and recent observations pertinent to early detection of PDAC in these risk groups and outlines future approaches that will potentially advance the field.
KW - early detection
KW - pancreatic adenocarcinoma
KW - pancreatic cancer screening
KW - pancreatic ductal adenocarcinoma
UR - http://www.scopus.com/inward/record.url?scp=85114089445&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85114089445&partnerID=8YFLogxK
U2 - 10.1097/mog.0000000000000770
DO - 10.1097/mog.0000000000000770
M3 - Review article
C2 - 34387255
AN - SCOPUS:85114089445
SN - 0267-1379
VL - 37
SP - 532
EP - 538
JO - Current opinion in gastroenterology
JF - Current opinion in gastroenterology
IS - 5
ER -