TY - JOUR
T1 - Early detection of bronchiolitis obliterans syndrome in lung transplant recipients with chronic rejection using home spirometry
AU - Finkelstein, S. M.
AU - Hertz, M. I.
AU - Snyder, M.
AU - Stibbe, C. Edin
AU - Sabati, N.
AU - Lindgren, B.
AU - Dutta, P.
AU - Killoren, T.
AU - Slagle, J.
PY - 1997/12/1
Y1 - 1997/12/1
N2 - Declining pulmonary function, as measured by staging for bronchiolitis obliterans syndrome, is considered a primary indication of future chronic rejection in transplanted lungs. Staging has been evaluated in a group of transplant recipients using a paperless, electronic spirometer/diary instrument for home monitoring. Eleven of 104 lung recipients were diagnosed with chronic rejection. Seven of these subjects had performed home monitoring for a minimum of 8 months at the time of this study. Clinic and home spirometry variables were used in the staging algorithm to determine the onset and rate of clinical decline related to the rejection. Using home spirometry, the onset of decline began an average of 284 days before diagnosis or chronic rejection, which was significantly earlier (p<0.05) than the decline observed with clinic pulmonary function testing. Staging changes based on home spirometry preceded diagnosis of chronic rejection in all subjects, but only occurred in 4 of 7 subjects using clinic testing. Home spirometry can provide early and consistent indication of pulmonary decline prior to chronic rejection, and should be considered as a future component of post-transplant follow-up care.
AB - Declining pulmonary function, as measured by staging for bronchiolitis obliterans syndrome, is considered a primary indication of future chronic rejection in transplanted lungs. Staging has been evaluated in a group of transplant recipients using a paperless, electronic spirometer/diary instrument for home monitoring. Eleven of 104 lung recipients were diagnosed with chronic rejection. Seven of these subjects had performed home monitoring for a minimum of 8 months at the time of this study. Clinic and home spirometry variables were used in the staging algorithm to determine the onset and rate of clinical decline related to the rejection. Using home spirometry, the onset of decline began an average of 284 days before diagnosis or chronic rejection, which was significantly earlier (p<0.05) than the decline observed with clinic pulmonary function testing. Staging changes based on home spirometry preceded diagnosis of chronic rejection in all subjects, but only occurred in 4 of 7 subjects using clinic testing. Home spirometry can provide early and consistent indication of pulmonary decline prior to chronic rejection, and should be considered as a future component of post-transplant follow-up care.
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M3 - Conference article
AN - SCOPUS:0031294246
SN - 1557-170X
VL - 3
SP - 1070
EP - 1072
JO - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
JF - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
T2 - Proceedings of the 1997 19th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Y2 - 30 October 1997 through 2 November 1997
ER -