Early cytomegalovirus reactivation remains associated with increased transplant-related mortality in the current era: A CIBMTR analysis

Pierre Teira, Minoo Battiwalla, Muthalagu Ramanathan, A. John Barrett, Kwang Woo Ahn, Min Chen, Jaime S. Green, Ayman Saad, Joseph H. Antin, Bipin N. Savani, Hillard M. Lazarus, Matthew Seftel, Wael Saber, David Marks, Mahmoud Aljurf, Maxim Norkin, John R. Wingard, Caroline A. Lindemans, Michael Boeckh, Marcie L. RichesJeffery J. Auletta

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269 Scopus citations


Single-center studies have reported an association between early (before day 100) cytomegalovirus (CMV) reactivation and decreased incidence of relapse for acute myeloid leukemia (AML) following allogeneic hematopoietic cell transplantation. To substantiate these preliminary findings, the Center for International Blood and Marrow Transplant Research (CIBMTR) Database was interrogated to analyze the impact of CMV reactivation on hematologic disease relapse in the current era. Data from 9469 patients transplanted with bone marrow or peripheral blood between 2003 and 2010 were analyzed according to 4 disease categories: AML (n = 5310); acute lymphoblastic leukemia (ALL, n = 1883); chronic myeloid leukemia (CML, n = 1079); and myelodysplastic syndrome (MDS, n = 1197). Median time to initial CMV reactivation was 41 days (range, 1-362 days). CMV reactivation had no preventive effect on hematologic disease relapse irrespective of diagnosis. Moreover, CMV reactivation was associated with higher nonrelapse mortality [relative risk [RR] among disease categories ranged from 1.61 to 1.95 and P values from .0002 to <.0001; 95% confidence interval [CI], 1.14-2.61). As a result, CMV reactivation was associated with lower overall survival for AML (RR = 1.27; 95% CI, 1.17-1.38; P <.0001), ALL (RR = 1.46; 95% CI, 1.25-1.71; P <.0001), CML (RR = 1.49; 95% CI, 1.19-1.88; P = .0005), and MDS (RR = 1.31; 95% CI, 1.09-1.57; P = .003). In conclusion, CMV reactivation continues to remain a risk factor for poor posttransplant outcomes and does not seem to confer protection against hematologic disease relapse.

Original languageEnglish (US)
Pages (from-to)2427-2438
Number of pages12
Issue number20
StatePublished - May 19 2016

Bibliographical note

Funding Information:
C.A.L. has consulted for Chimerix. M. Boeckh has consulted for Genentech, Chimerix Inc, Merck, Shire, Clinigen, and Astellas and has received research support from Roche Molecular Systems. All other authors declare no competing financial interests.

Publisher Copyright:
© 2016, American Society of Hematology. All rights reserved.


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