Early circulating erythroid progenitor cells and expression of erythropoietin receptors in sickle cell disease

R. C R Perlingeiro, F. F. Costa, S. T O Saad, M. L S Queiroz

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

The ability of circulating progenitor cells from 22 patients with sickle cell disease (SCD) to develop erythroid colonies was studied in vitro in the presence or absence of growth factors (5637-CM and erythropoietin). In both conditions, SCD patients presented significantlyshigher numbers of circulating burst-forming unit-erythroid (BFU-E/5x105 MNC) when compared to control subjects. The study of the expression of erythropoietin receptors revealed an increased level in SCD patients. Moreover, there was a correlation between both stimulated and autocrine (without stimulus) BFU-E and the expression of erythropoietin receptors. These results are of particular interest since they indicate that the phenomenon of spontaneous BFU-E-derived colonies observed in SCD patients may be due to an increased expression of erythropoietin receptors.

Original languageEnglish (US)
Pages (from-to)226-232
Number of pages7
JournalEuropean Journal of Haematology
Volume60
Issue number4
DOIs
StatePublished - Jan 1 1998

Keywords

  • Autoproliferation
  • BFU-E
  • Epo receptore
  • Haematopmesis
  • Sickle call disease

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