Early circulating erythroid progenitor cells and expression of erythropoietin receptors in sickle cell disease

R. C R Perlingeiro; F. F. Costa; S. T O Saad; M. L S Queiroz

doi:10.1111/j.1600-0609.1998.tb01028.x

Early circulating erythroid progenitor cells and expression of erythropoietin receptors in sickle cell disease

R. C R Perlingeiro, F. F. Costa, S. T O Saad, M. L S Queiroz

Medicine - Cardiology Division

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The ability of circulating progenitor cells from 22 patients with sickle cell disease (SCD) to develop erythroid colonies was studied in vitro in the presence or absence of growth factors (5637-CM and erythropoietin). In both conditions, SCD patients presented significantlyshigher numbers of circulating burst-forming unit-erythroid (BFU-E/5x10⁵ MNC) when compared to control subjects. The study of the expression of erythropoietin receptors revealed an increased level in SCD patients. Moreover, there was a correlation between both stimulated and autocrine (without stimulus) BFU-E and the expression of erythropoietin receptors. These results are of particular interest since they indicate that the phenomenon of spontaneous BFU-E-derived colonies observed in SCD patients may be due to an increased expression of erythropoietin receptors.

Original language	English (US)
Pages (from-to)	226-232
Number of pages	7
Journal	European Journal of Haematology
Volume	60
Issue number	4
DOIs	https://doi.org/10.1111/j.1600-0609.1998.tb01028.x
State	Published - Jan 1 1998

Keywords

Autoproliferation
BFU-E
Epo receptore
Haematopmesis
Sickle call disease

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title = "Early circulating erythroid progenitor cells and expression of erythropoietin receptors in sickle cell disease",

abstract = "The ability of circulating progenitor cells from 22 patients with sickle cell disease (SCD) to develop erythroid colonies was studied in vitro in the presence or absence of growth factors (5637-CM and erythropoietin). In both conditions, SCD patients presented significantlyshigher numbers of circulating burst-forming unit-erythroid (BFU-E/5x105 MNC) when compared to control subjects. The study of the expression of erythropoietin receptors revealed an increased level in SCD patients. Moreover, there was a correlation between both stimulated and autocrine (without stimulus) BFU-E and the expression of erythropoietin receptors. These results are of particular interest since they indicate that the phenomenon of spontaneous BFU-E-derived colonies observed in SCD patients may be due to an increased expression of erythropoietin receptors.",

keywords = "Autoproliferation, BFU-E, Epo receptore, Haematopmesis, Sickle call disease",

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AU - Perlingeiro, R. C R

AU - Costa, F. F.

AU - Saad, S. T O

AU - Queiroz, M. L S

PY - 1998/1/1

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N2 - The ability of circulating progenitor cells from 22 patients with sickle cell disease (SCD) to develop erythroid colonies was studied in vitro in the presence or absence of growth factors (5637-CM and erythropoietin). In both conditions, SCD patients presented significantlyshigher numbers of circulating burst-forming unit-erythroid (BFU-E/5x105 MNC) when compared to control subjects. The study of the expression of erythropoietin receptors revealed an increased level in SCD patients. Moreover, there was a correlation between both stimulated and autocrine (without stimulus) BFU-E and the expression of erythropoietin receptors. These results are of particular interest since they indicate that the phenomenon of spontaneous BFU-E-derived colonies observed in SCD patients may be due to an increased expression of erythropoietin receptors.

AB - The ability of circulating progenitor cells from 22 patients with sickle cell disease (SCD) to develop erythroid colonies was studied in vitro in the presence or absence of growth factors (5637-CM and erythropoietin). In both conditions, SCD patients presented significantlyshigher numbers of circulating burst-forming unit-erythroid (BFU-E/5x105 MNC) when compared to control subjects. The study of the expression of erythropoietin receptors revealed an increased level in SCD patients. Moreover, there was a correlation between both stimulated and autocrine (without stimulus) BFU-E and the expression of erythropoietin receptors. These results are of particular interest since they indicate that the phenomenon of spontaneous BFU-E-derived colonies observed in SCD patients may be due to an increased expression of erythropoietin receptors.

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KW - BFU-E

KW - Epo receptore

KW - Haematopmesis

KW - Sickle call disease

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Early circulating erythroid progenitor cells and expression of erythropoietin receptors in sickle cell disease

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Keywords

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