Early biochemical and EEG correlates of the ketogenic diet in children with atypical absence epilepsy

Diana L. Ross, Kenneth F Swaiman, Fernando Torres, Jessie Hansen

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Early changes in blood chemistry and the electroencephalogram were monitored during the first three hours after initiating the medium chain triglyceride (MCT) diet in nine children with intractable atypical absence seizures. Serum glucose, insulin, triglycerides, cholesterol, free fatty acids, ketone bodies concentrations, and venous pH were assayed before and at timed intervals after MCT oil was administered orally. The concentration of serum ketones rose progressively over three hours, β-hydroxybutyrate proportionately higher than acetoacetate. A statistically significant decrease in the group mean number of epileptiform discharges occurred following MCT therapy. Seizure frequency decreased by more than 50 percent in two-thirds of the children during the 10 week treatment period.

Original languageEnglish (US)
Pages (from-to)104-108
Number of pages5
JournalPediatric Neurology
Volume1
Issue number2
DOIs
StatePublished - Jan 1 1985

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