E3 ubiquitin ligases and their control of T cell autoreactivity

Jody L. Bonnevier, Ruan Zhang, Daniel L Mueller

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations


A loss of T cell tolerance underlies the development of most autoimmune diseases. The design of therapeutic strategies to re-institute immune tolerance, however, is hampered by uncertainty regarding the molecular mechanisms involved in the inactivation of potentially autoreactive T cells. Recently, E3 ubiquitin ligases have been shown to mediate the development of a durable state of unresponsiveness in T cells called clonal anergy. In this review, we will discuss the mechanisms used by E3 ligases to control the activation of T cells and prevent the development of autoimmunity.

Original languageEnglish (US)
Pages (from-to)233-242
Number of pages10
JournalArthritis Research and Therapy
Issue number6
StatePublished - Dec 2005


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