Dynorphin blocks opioid inhibition of macrophage-colony stimulating factor-induced proliferation of bone marrow cells

Sabita Roy, Horace H. Loh, Nancy M. Lee

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

We previously reported that morphine inhibits macrophage-colony stimulating factor (M-CSF)-induced proliferation of mouse bone marrow cells, both in vivo and in vitro, in a dose-dependent manner. We now report that either dynorphin A-(1-13) or dynorphin A-(1-10) amide, though having no effect on proliferation by themselves at concentrations less than 0.1 mM, can block the inhibitory effect of morphine both in vivo and in vitro, in a dose-dependent manner. The opioid antagonist naloxone can also block morphine's inhibitory effect on bone marrow cell proliferation in vivo, but has no effect in vitro. Dynorphin A-(1-13) was also able to block the dramatic reduction of spleen weight observed in animals chronically treated with morphine. Thus dynorphin, which has previously been shown to antagonize morphine analgesia, is also able to antagonize some of the immunosuppressive effects of morphine.

Original languageEnglish (US)
Pages (from-to)355-359
Number of pages5
JournalEuropean Journal of Pharmacology
Volume202
Issue number3
DOIs
StatePublished - Sep 24 1991

Keywords

  • Bone marrow cells
  • Dynorphin
  • M-CSF (macrophage-colony stimulating factor)
  • Morphine

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