Dynorphin-(1-13) induces spontaneous feeding in rats

John E. Morley, Allen S. Levine

Research output: Contribution to journalArticlepeer-review

202 Scopus citations

Abstract

Dynorphin-(1-13), a recently isolated opioid peptide stimulates food ingestion in rats after intracerebroventricular administration at doses of 1 and 10 μg. The latency until food ingestion is 22.4 ± 1.9 min. The ability of dynorphin-(1-13) to initiate food ingestion is antagonized by the opiate antagonist, naloxone. The food ingestion is accompanied by excessive grooming behavior.

Original languageEnglish (US)
Pages (from-to)1901-1903
Number of pages3
JournalLife Sciences
Volume29
Issue number18
DOIs
StatePublished - Nov 2 1981

Bibliographical note

Funding Information:
We thank Julie Kneip and Martha Grace for and JoAnn Tallman for secretarial assistance. were supported by the Veterans Administration.

Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.

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