Dynamics of the hippocampus during encoding and retrieval of face-name pairs

Michael M. Zeineh, Stephen A. Engel, Paul M. Thompson, Susan Y. Bookheimer

Research output: Contribution to journalArticle

375 Scopus citations

Abstract

The medial temporal lobe (MTL) is critical in forming new memories, but how subregions Within the MTL carry out encoding and retrieval processes in humans is unknown. Using new high-resolution functional magnetic resonance imaging (fMRI) acquisition and analysis methods, we identified mnemonic properties of different subregions within the hippocampal circuitry as human subjects learned to associate names with faces. The cornu ammonis (CA) fields 2 and 3 and the dentate gyrus were active relative to baseline only during encoding, and this activity decreased as associations were learned. Activity in the subiculum showed the same temporal decline, but primarily during retrieval. Our results demonstrate that subdivisions within the hippocampus make distinct contributions to new memory formation.

Original languageEnglish (US)
Pages (from-to)577-580
Number of pages4
JournalScience
Volume299
Issue number5606
DOIs
StatePublished - Jan 24 2003

Fingerprint Dive into the research topics of 'Dynamics of the hippocampus during encoding and retrieval of face-name pairs'. Together they form a unique fingerprint.

  • Cite this