Dynamics of Microtubule Self-Assembly

Research output: Chapter in Book/Report/Conference proceedingChapter


Microtubules are linear intracellular polymers that self-assemble from subunits of αβ-tubulin heterodimers, and serve as essential mediators of cellular processes including cell division, migration, as well as intracellular transport. Each of these functions is dependent on the microtubule structure and self-assembly dynamics. Here we discuss the dynamics of microtubule structure and subunit addition and loss in the process of microtubule self-assembly, highlighting how these nanometer/molecular-scale dynamics manifest themselves at the micrometer/cellular-scale.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Cell Biology
Subtitle of host publicationVolume 1-6, Second Edition
Number of pages10
ISBN (Electronic)9780128216248
StatePublished - Jan 1 2022

Bibliographical note

Publisher Copyright:
© 2023 Elsevier Inc. All rights reserved.


  • Catastrophe
  • Dynamic instability
  • GTP cap
  • Hydrolysis
  • Kinetic stabilization
  • Kinetics
  • MAPs
  • Microtubule
  • Rescue
  • Self-assembly
  • Thermodynamics


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