Dynamics of Microtubule Self-Assembly

B. T. Castle, D. J. Odde

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Microtubules are linear intracellular polymers that self-assemble from subunits of αβ-tubulin heterodimers, and serve as essential mediators of cellular processes including cell division, migration, as well as intracellular transport. Each of these functions is dependent on the microtubule structure and self-assembly dynamics. Here we discuss the dynamics of microtubule structure and subunit addition and loss in the process of microtubule self-assembly, highlighting how these nanometer/molecular-scale dynamics manifest themselves at the micrometer/cellular-scale.

Original languageEnglish (US)
Title of host publicationSystems Cell Biology
PublisherElsevier Inc.
Pages36-43
Number of pages8
Volume4
ISBN (Electronic)9780123944474
ISBN (Print)9780123947963
DOIs
StatePublished - Jan 1 2016

Keywords

  • Catastrophe
  • Dynamic instability
  • GTP cap
  • Hydrolysis
  • Kinetic stabilization
  • Kinetics
  • MAPs
  • Microtubule
  • Rescue
  • Self-assembly
  • Thermodynamics

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