Dynamics of lactate concentration and blood oxygen level-dependent effect in the human visual cortex during repeated identical stimuli

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Abstract

In vivo 1H NMR spectroscopy at 7 T was utilized to measure the changes in lactate concentration upon repeated identical visual stimuli, each lasting for 2 min. The average amplitude of these increases was found to be reduced over time (P < 0.01), from 0.13 ± 0.02 μmol/g during the first half of the stimulation paradigm, to 0.06 ± 0.02 μmol/g during the second half of the stimulation paradigm. In contrast, the blood oxygen level-dependent (BOLD) effect on the fMRI water signal and on the height of the total creatine signal at 3.03 ppm was persistent during the whole observation period. This finding may suggest a differential adaptation of cortical output that is not reflected at the level of the global excitation-inhibition activity of the cortical canonical circuits. Alternative possibilities that could account for an adaptation of [Lac] changes are also discussed.

Original languageEnglish (US)
Pages (from-to)3340-3346
Number of pages7
JournalJournal of Neuroscience Research
Volume85
Issue number15
DOIs
StatePublished - Nov 15 2007

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Creatine
Visual Cortex
Lactic Acid
Magnetic Resonance Spectroscopy
Magnetic Resonance Imaging
Observation
Oxygen
Water
Proton Magnetic Resonance Spectroscopy

Keywords

  • Adaptation
  • Brain activation
  • Functional metabolism

Cite this

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title = "Dynamics of lactate concentration and blood oxygen level-dependent effect in the human visual cortex during repeated identical stimuli",
abstract = "In vivo 1H NMR spectroscopy at 7 T was utilized to measure the changes in lactate concentration upon repeated identical visual stimuli, each lasting for 2 min. The average amplitude of these increases was found to be reduced over time (P < 0.01), from 0.13 ± 0.02 μmol/g during the first half of the stimulation paradigm, to 0.06 ± 0.02 μmol/g during the second half of the stimulation paradigm. In contrast, the blood oxygen level-dependent (BOLD) effect on the fMRI water signal and on the height of the total creatine signal at 3.03 ppm was persistent during the whole observation period. This finding may suggest a differential adaptation of cortical output that is not reflected at the level of the global excitation-inhibition activity of the cortical canonical circuits. Alternative possibilities that could account for an adaptation of [Lac] changes are also discussed.",
keywords = "Adaptation, Brain activation, Functional metabolism",
author = "Silvia Mangia and Ivan Tk{\'a}č and Logothetis, {Nikos K.} and Rolf Gruetter and {Van De Moortele}, {Pierre Francois} and K{\^a}mil Uǧurbil",
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T1 - Dynamics of lactate concentration and blood oxygen level-dependent effect in the human visual cortex during repeated identical stimuli

AU - Mangia, Silvia

AU - Tkáč, Ivan

AU - Logothetis, Nikos K.

AU - Gruetter, Rolf

AU - Van De Moortele, Pierre Francois

AU - Uǧurbil, Kâmil

PY - 2007/11/15

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N2 - In vivo 1H NMR spectroscopy at 7 T was utilized to measure the changes in lactate concentration upon repeated identical visual stimuli, each lasting for 2 min. The average amplitude of these increases was found to be reduced over time (P < 0.01), from 0.13 ± 0.02 μmol/g during the first half of the stimulation paradigm, to 0.06 ± 0.02 μmol/g during the second half of the stimulation paradigm. In contrast, the blood oxygen level-dependent (BOLD) effect on the fMRI water signal and on the height of the total creatine signal at 3.03 ppm was persistent during the whole observation period. This finding may suggest a differential adaptation of cortical output that is not reflected at the level of the global excitation-inhibition activity of the cortical canonical circuits. Alternative possibilities that could account for an adaptation of [Lac] changes are also discussed.

AB - In vivo 1H NMR spectroscopy at 7 T was utilized to measure the changes in lactate concentration upon repeated identical visual stimuli, each lasting for 2 min. The average amplitude of these increases was found to be reduced over time (P < 0.01), from 0.13 ± 0.02 μmol/g during the first half of the stimulation paradigm, to 0.06 ± 0.02 μmol/g during the second half of the stimulation paradigm. In contrast, the blood oxygen level-dependent (BOLD) effect on the fMRI water signal and on the height of the total creatine signal at 3.03 ppm was persistent during the whole observation period. This finding may suggest a differential adaptation of cortical output that is not reflected at the level of the global excitation-inhibition activity of the cortical canonical circuits. Alternative possibilities that could account for an adaptation of [Lac] changes are also discussed.

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KW - Brain activation

KW - Functional metabolism

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