Dynamic optimization of signal transduction via intrinsic disorder

L. Michel Espinoza-Fonseca

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

It is widely accepted that the inherent flexibility of intrinsically disordered proteins (IDPs) correlates with essential functions in the cell such as signaling. However, the mechanisms by which disorder dynamically facilitates and optimizes signal transduction remain unclear. In this study, we have used a computational protocol to evaluate the interplay between the intrinsic disorder of p27 kip1 and the collective motions of its binding partners, cyclin dependent kinase 2 (CDK2) and cyclin A (CA). We found that the synergy between intrinsic disorder of p27 kip1 and the essential collective motions of the CDK2-CA complex introduces a set of sequential steps to dynamically optimize signal transduction. Our observations indicate that optimized p27 kip1-mediated signaling originates from a combination of adaptive folding, and the cooperativity between its residual disorder and the functional collective motions of the CDK2-CA complex.

Original languageEnglish (US)
Pages (from-to)194-197
Number of pages4
JournalMolecular BioSystems
Volume8
Issue number1
DOIs
StatePublished - Jan 1 2012

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