Dynamic imaging of tumor vasculature in rodents: Carbogen-induced contrast enhancement

Kenneth T. Kotz, Konstantinos S. Kalogerakis, William N. Boenig, Khalid Amin, Gregory W. Faris

Research output: Contribution to journalConference articlepeer-review

5 Scopus citations


We have studied the dynamic changes in tissue vasculature following the inhalation of hyperoxic gasses in rodents as a model for optical breast cancer detection. We have used a CW apparatus to measure the near infrared (NIR) optical properties of animal models immersed in a liquid tissue phantom. By looking at the transmission of different wavelengths in the NIR, we were able to qualitatively observe changes in blood oxygenation following the inhalation of different mixtures of CO 2 and O 2. These changes enhanced the image contrast between cancerous tissue and normal tissues of the rodents. The oxygenation dynamics of the tumors, following inhalation of the hyperoxic gases, exhibited differences from surrounding tissues in both the magnitude of the observed signal change and the dynamic response.

Original languageEnglish (US)
Article number54
Pages (from-to)273-277
Number of pages5
JournalProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Issue number1
StatePublished - Dec 1 2004
EventLasers in Surgery: Advanced Characterization, Therapeutics, and Systems XIV - San Jose, CA, United States
Duration: Jan 24 2004Jan 27 2004


  • Animal models
  • Breast cancer
  • Compensated transillumination
  • In vivo imaging contrast enhancement
  • Tumor detection
  • Tumor vasculature


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