Dynamic correlations between hemodynamic, metabolic, and neuronal responses to acute whole-brain ischemia

Jennifer M. Taylor, Xiao Hong Zhu, Yi Zhang, Wei Chen

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Cerebral ischemia sets off a cascade of neuronal and metabolic responses to preserve brain viability. An understanding of the temporal evolution of these changes during and after ischemia, and their correlation with hemodynamic changes, is essential. In this study, a 12-min whole-brain ischemia based on the four-blood-vessel occlusion model was employed in rats. Using a high-temporal-resolution simultaneous 1H-31P MRS acquisition sequence at 9.4T, we investigated dynamic occlusion and reperfusion responses in cerebral lactate (Lac), phosphocreatine (PCr), adenosine triphosphate (ATP), pH, and blood oxygenation level dependence (BOLD), together with changes in neuronal field potential activity. We reveal tightly coupled dynamics between hemodynamic, metabolic, and neuronal responses to ischemia. Neuronal activity, BOLD, PCr, Lac, and pH changed immediately following occlusion, indicating reduced energy substrates and consumption, and increased glycolysis to maintain cellular ATP levels, which started to decrease 2.2min after the onset of occlusion. ATP stores were then gradually consumed to maintain a minimum housekeeping neuronal activity level. By correlating dynamic changes of brain activity, BOLD, and energy metabolism, new insights into the brain's survival ability and mechanisms during an acute ischemic attack from the perspectives of cerebral metabolism, neuroenergetics, and neuronal activity were gained.

Original languageEnglish (US)
Pages (from-to)1357-1365
Number of pages9
JournalNMR in biomedicine
Volume28
Issue number11
DOIs
StatePublished - Nov 2015

Fingerprint

Hemodynamics
Brain Ischemia
Oxygenation
Brain
Phosphocreatine
Adenosine Triphosphate
Blood
Lactic Acid
Ischemia
Matrix Attachment Regions
Housekeeping
Glycolysis
Energy Metabolism
Reperfusion
Blood Vessels
Blood vessels
Metabolism
Rats
Substrates

Keywords

  • Brain hemodynamics
  • Brain ischemia
  • Brain metabolism
  • Electrophysiology
  • MRS
  • Simultaneous acquisition

Cite this

Dynamic correlations between hemodynamic, metabolic, and neuronal responses to acute whole-brain ischemia. / Taylor, Jennifer M.; Zhu, Xiao Hong; Zhang, Yi; Chen, Wei.

In: NMR in biomedicine, Vol. 28, No. 11, 11.2015, p. 1357-1365.

Research output: Contribution to journalArticle

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