DXA-Determined Regional Adiposity Relates to Insulin Resistance in a Young Adult Population with Overweight andObesity

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Abstract

Obesity is a well-established risk factor for insulin resistance and type 2 diabetes mellitus, and body fat distribution has important implications for this metabolic risk. In this cross-sectional study, we used dual X-ray absorptiometry body composition data from 123 young adult participants with overweight or obesity, and correlatedwith 2 indices of insulin resistance calculated from oral glucose tolerance tests. Participants were 70% women, with mean (standard error) age 30.1 (0.6) yr, body mass index (BMI) 34.0 (0.6) kg/m 2 , homeostatic model assessment of insulin resistance (HOMA-IR) of 2.1 (0.2), and Matsuda insulin sensitivity index (Matsuda ISI) of 5.8 (0.4). In women, the strongest correlations were observed with the android-to-gynoid ratio (r = 0.52, p < 0.001 for HOMA-IR; r = −0.46, p < 0.001 for Matsuda ISI), and these correlations remained significant after adjustment for BMI. For men, the strongest correlations were with android fat mass (r = 0.40, p = 0.01 for HOMA-IR; r = −0.37, p = 0.02 for Matsuda ISI). Visceral adipose tissue was correlated with HOMA-IR and Matsuda ISI in women, and only with Matsuda ISI in men. BMI correlated with HOMA-IR and with Matsuda ISI in both women and men. Regional adiposity determined by dual X-ray absorptiometry correlates with indices of insulin resistance in sedentary young adults with overweight and obesity.

Original languageEnglish (US)
Pages (from-to)287-292
Number of pages6
JournalJournal of Clinical Densitometry
Volume22
Issue number2
DOIs
StatePublished - Apr 1 2019

Bibliographical note

Funding Information:
Research reported in this publication was supported bythe National Institute of Diabetes and Digestive and Kidney Diseases with award numbers 1R01DK098203 and T32DK007203, and the National Center for AdvancingTranslational Sciences with award number UL1TR000114, all of the National Institutes of Health.

Funding Information:
Research reported in this publication was supported by the National Institute of Diabetes and Digestive and Kidney Diseases with award numbers 1R01DK098203 and T32DK007203 , and the National Center for Advancing Translational Sciences with award number UL1TR000114 , all of the National Institutes of Health.

Publisher Copyright:
© 2018 The International Society for Clinical Densitometry

Keywords

  • Body composition
  • DXA
  • HOMA-IR
  • Matsuda index
  • insulin resistance

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