Dual roles of hyaluronic acids in multilayer films capturing nanocarriers for drug-eluting coatings

Saibom Park, Suk Ho Bhang, Wan Geun La, Jinhwa Seo, Byung Soo Kim, Kookheon Char

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

We developed hyaluronic acid (HA)-based multilayer films capturing polymeric nanocarriers (NCs) for drug delivery. The electrostatic interactions between positively charged linear polyethylene imines (LPEI) and negatively charged HAs are the main driving forces to form multilayers based on the layer-by-layer (LbL) deposition. NCs were easily incorporated within the multilayer film due to intra- and/or inter-hydrogen bonding among HA chains. The amount of NCs captured by the HA chains was varied by the ratio between HAs and NCs as well as the length (i.e., molecular weight) and absolute number density of HAs in solution. Biocompatibility of the NC-capturing HA multilayer films was tested with the human dermal fibroblast (HDF) culture. In addition, the controlled release of paclitaxel (PTX) from the HA multilayer films successfully led to the apoptosis of human aortic smooth muscle cells (hSMC) in vitro, implying that the NC-capturing HA multilayer films would be quite useful as drug-eluting stent systems to prevent the restenosis after surgery.

Original languageEnglish (US)
Pages (from-to)5468-5477
Number of pages10
JournalBiomaterials
Volume33
Issue number21
DOIs
StatePublished - Jul 1 2012

Keywords

  • Controlled drug release
  • Hyaluronic acid(s)
  • Hydrogel(s)
  • Layer-by-layer assembly
  • Nanocarrier(s)
  • Paclitaxel

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