Abstract
We developed hyaluronic acid (HA)-based multilayer films capturing polymeric nanocarriers (NCs) for drug delivery. The electrostatic interactions between positively charged linear polyethylene imines (LPEI) and negatively charged HAs are the main driving forces to form multilayers based on the layer-by-layer (LbL) deposition. NCs were easily incorporated within the multilayer film due to intra- and/or inter-hydrogen bonding among HA chains. The amount of NCs captured by the HA chains was varied by the ratio between HAs and NCs as well as the length (i.e., molecular weight) and absolute number density of HAs in solution. Biocompatibility of the NC-capturing HA multilayer films was tested with the human dermal fibroblast (HDF) culture. In addition, the controlled release of paclitaxel (PTX) from the HA multilayer films successfully led to the apoptosis of human aortic smooth muscle cells (hSMC) in vitro, implying that the NC-capturing HA multilayer films would be quite useful as drug-eluting stent systems to prevent the restenosis after surgery.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 5468-5477 |
| Number of pages | 10 |
| Journal | Biomaterials |
| Volume | 33 |
| Issue number | 21 |
| DOIs | |
| State | Published - Jul 2012 |
| Externally published | Yes |
Bibliographical note
Funding Information:This work was financially supported by the National Research Foundation of Korea (NRF) funded by the Korea Ministry of Education, Science, and Technology (MEST) ( The National Creative Research Initiative Program for “Intelligent Hybrids Research Center” (No. 2010-0018290 ), the Brain Korea 21 Program in SNU Chemical Engineering, and the WCU Program of Chemical Convergence for Energy and Environment ( R31-10013 )) and the Korea Health 21 R&D Project (A101539) of the Ministry of Health and Welfare of Korea.
Keywords
- Controlled drug release
- Hyaluronic acid(s)
- Hydrogel(s)
- Layer-by-layer assembly
- Nanocarrier(s)
- Paclitaxel