Dual-responsive supramolecular hydrogels from water-soluble PEG-grafted copolymers and cyclodextrin

Lixia Ren; Lihong He; Tongchen Sun; Xia Dong; Yongming Chen; Jin Huang; Chun Wang

doi:10.1002/mabi.200900021

Dual-responsive supramolecular hydrogels from water-soluble PEG-grafted copolymers and cyclodextrin

Lixia Ren, Lihong He, Tongchen Sun, Xia Dong, Yongming Chen, Jin Huang, Chun Wang

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

67 Scopus citations

Abstract

Novel temperature and pH dual-responsive hydrogels were constructed by inclusion of poly(PEGMA)-co-poly(DMA) with α-cyclodextrin in aqueous solution. The temperature- or pH-induced sol/gel transition in the hydrogels was completely reversible. Studies on structure/property relationships show that chain uniformity, graft density and copolymer concentration affect the hydrogel behavior. A dual-responsive mechanism is proposed. The in vitro release of a model drug from this hydrogel was studied. It was found that the release kinetics were greatly accelerated at higher temperature and at acidic pH conditions, indicating potential applications in controlled drug delivery. (Figure Presented).

Original language	English (US)
Pages (from-to)	902-910
Number of pages	9
Journal	Macromolecular Bioscience
Volume	9
Issue number	9
DOIs	https://doi.org/10.1002/mabi.200900021
State	Published - Sep 9 2009

Keywords

Cyclodextrins
Drug delivery
Grafted copolymers
Hydrogels
Stimulus responsive

Publisher link

10.1002/mabi.200900021

Find It

Find It at U of M Libraries

Cite this

@article{0a86bf949f8b414dac7a8392f23640aa,

title = "Dual-responsive supramolecular hydrogels from water-soluble PEG-grafted copolymers and cyclodextrin",

abstract = "Novel temperature and pH dual-responsive hydrogels were constructed by inclusion of poly(PEGMA)-co-poly(DMA) with α-cyclodextrin in aqueous solution. The temperature- or pH-induced sol/gel transition in the hydrogels was completely reversible. Studies on structure/property relationships show that chain uniformity, graft density and copolymer concentration affect the hydrogel behavior. A dual-responsive mechanism is proposed. The in vitro release of a model drug from this hydrogel was studied. It was found that the release kinetics were greatly accelerated at higher temperature and at acidic pH conditions, indicating potential applications in controlled drug delivery. (Figure Presented).",

keywords = "Cyclodextrins, Drug delivery, Grafted copolymers, Hydrogels, Stimulus responsive",

author = "Lixia Ren and Lihong He and Tongchen Sun and Xia Dong and Yongming Chen and Jin Huang and Chun Wang",

year = "2009",

month = sep,

day = "9",

doi = "10.1002/mabi.200900021",

language = "English (US)",

volume = "9",

pages = "902--910",

journal = "Macromolecular Bioscience",

issn = "1616-5187",

publisher = "Wiley-VCH Verlag",

number = "9",

}

TY - JOUR

T1 - Dual-responsive supramolecular hydrogels from water-soluble PEG-grafted copolymers and cyclodextrin

AU - Ren, Lixia

AU - He, Lihong

AU - Sun, Tongchen

AU - Dong, Xia

AU - Chen, Yongming

AU - Huang, Jin

AU - Wang, Chun

PY - 2009/9/9

Y1 - 2009/9/9

N2 - Novel temperature and pH dual-responsive hydrogels were constructed by inclusion of poly(PEGMA)-co-poly(DMA) with α-cyclodextrin in aqueous solution. The temperature- or pH-induced sol/gel transition in the hydrogels was completely reversible. Studies on structure/property relationships show that chain uniformity, graft density and copolymer concentration affect the hydrogel behavior. A dual-responsive mechanism is proposed. The in vitro release of a model drug from this hydrogel was studied. It was found that the release kinetics were greatly accelerated at higher temperature and at acidic pH conditions, indicating potential applications in controlled drug delivery. (Figure Presented).

AB - Novel temperature and pH dual-responsive hydrogels were constructed by inclusion of poly(PEGMA)-co-poly(DMA) with α-cyclodextrin in aqueous solution. The temperature- or pH-induced sol/gel transition in the hydrogels was completely reversible. Studies on structure/property relationships show that chain uniformity, graft density and copolymer concentration affect the hydrogel behavior. A dual-responsive mechanism is proposed. The in vitro release of a model drug from this hydrogel was studied. It was found that the release kinetics were greatly accelerated at higher temperature and at acidic pH conditions, indicating potential applications in controlled drug delivery. (Figure Presented).

KW - Cyclodextrins

KW - Drug delivery

KW - Grafted copolymers

KW - Hydrogels

KW - Stimulus responsive

UR - http://www.scopus.com/inward/record.url?scp=70449623313&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70449623313&partnerID=8YFLogxK

U2 - 10.1002/mabi.200900021

DO - 10.1002/mabi.200900021

M3 - Article

C2 - 19544291

AN - SCOPUS:70449623313

SN - 1616-5187

VL - 9

SP - 902

EP - 910

JO - Macromolecular Bioscience

JF - Macromolecular Bioscience

IS - 9

ER -

Dual-responsive supramolecular hydrogels from water-soluble PEG-grafted copolymers and cyclodextrin

Abstract

Keywords

Publisher link

Find It

Other files and links

Fingerprint

Cite this