Dual pharmacotherapy and motivational interviewing for tobacco dependence among drug treatment patients

Kimber P. Richter, Robert M. McCool, Delwyn Catley, Matthew Hall, Jasjit S. Ahluwalia

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


This pilot study is the first to examine the feasibility and outcomes of dual pharmacotherapy for smoking cessation among drug treatment patients. The intervention consisted of 7 weeks of bupropion (300 mg), 12 weeks of nicotine gum, and 6 sessions of motivational interviewing. The trial was conducted among 28 patients recruited from 5 methadone clinics and employed a pretest-posttest design. At 6 months post quit date, 14% of participants met criteria for biochemically-verified abstinence. Among those still smoking, number of cigarettes smoked decreased significantly and most (88%) had made at least 1 serious quit attempt. Participation rates were excellent and no adverse effects on alcohol or illicit drug use were found. Although not a definitive test of the intervention, findings suggest that a multi-component approach to tobacco dependence is feasible and potentially effective in helping drug treatment patients achieve smoking cessation well beyond the end of treatment and that a large-scale randomized trial is warranted.

Original languageEnglish (US)
Pages (from-to)79-90
Number of pages12
JournalJournal of Addictive Diseases
Issue number4
StatePublished - 2005

Bibliographical note

Funding Information:
This study was supported by the National Institute on Drug Abuse (K01 DA00450). GlaxoSmithKline provided the nicotine gum for the trial but did not review any drafts of the manuscript.


  • Clinical trial
  • Drug treatment
  • Methadone
  • Smoking cessation
  • Tobacco


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