Dual effect of ketamine on the peripheral vasculature

J. C. Liao; Douglas E Koehntop; J. J. Buckley

Dual effect of ketamine on the peripheral vasculature

J. C. Liao, Douglas E Koehntop, J. J. Buckley

Anesthesiology

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

5 mg/kg Ketamine caused sympathetic mediated vasoconstriction and direct vasodilatation in the hind limb vasculature of dogs immediately after injection. The carotid arterial injection of Ketamine caused transient vasoconstriction of hind limb vasculature. Ketamine at low concentrations (5 μg/ml) did not show the uptake blockade of tritiated norepinephrine, but high concentrations (50 μg/ml and 500 μg/ml) exhibited a cocaine-like effect. At blood levels of Ketamine showing marked inhibition of norepinephrine uptake the direct depressant effect of Ketamine predominates.

Original language	English (US)
Pages (from-to)	S116
Journal	Anesthesiology
Volume	51
Issue number	3 SUPPL
State	Published - Jan 1 1979

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abstract = "5 mg/kg Ketamine caused sympathetic mediated vasoconstriction and direct vasodilatation in the hind limb vasculature of dogs immediately after injection. The carotid arterial injection of Ketamine caused transient vasoconstriction of hind limb vasculature. Ketamine at low concentrations (5 μg/ml) did not show the uptake blockade of tritiated norepinephrine, but high concentrations (50 μg/ml and 500 μg/ml) exhibited a cocaine-like effect. At blood levels of Ketamine showing marked inhibition of norepinephrine uptake the direct depressant effect of Ketamine predominates.",

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AU - Buckley, J. J.

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N2 - 5 mg/kg Ketamine caused sympathetic mediated vasoconstriction and direct vasodilatation in the hind limb vasculature of dogs immediately after injection. The carotid arterial injection of Ketamine caused transient vasoconstriction of hind limb vasculature. Ketamine at low concentrations (5 μg/ml) did not show the uptake blockade of tritiated norepinephrine, but high concentrations (50 μg/ml and 500 μg/ml) exhibited a cocaine-like effect. At blood levels of Ketamine showing marked inhibition of norepinephrine uptake the direct depressant effect of Ketamine predominates.

AB - 5 mg/kg Ketamine caused sympathetic mediated vasoconstriction and direct vasodilatation in the hind limb vasculature of dogs immediately after injection. The carotid arterial injection of Ketamine caused transient vasoconstriction of hind limb vasculature. Ketamine at low concentrations (5 μg/ml) did not show the uptake blockade of tritiated norepinephrine, but high concentrations (50 μg/ml and 500 μg/ml) exhibited a cocaine-like effect. At blood levels of Ketamine showing marked inhibition of norepinephrine uptake the direct depressant effect of Ketamine predominates.

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Dual effect of ketamine on the peripheral vasculature

Abstract

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