5 mg/kg Ketamine caused sympathetic mediated vasoconstriction and direct vasodilatation in the hind limb vasculature of dogs immediately after injection. The carotid arterial injection of Ketamine caused transient vasoconstriction of hind limb vasculature. Ketamine at low concentrations (5 μg/ml) did not show the uptake blockade of tritiated norepinephrine, but high concentrations (50 μg/ml and 500 μg/ml) exhibited a cocaine-like effect. At blood levels of Ketamine showing marked inhibition of norepinephrine uptake the direct depressant effect of Ketamine predominates.
|Original language||English (US)|
|Issue number||3 SUPPL|
|State||Published - Jan 1 1979|