Dual core processing: MRB1 is an emerging kinetoplast RNA editing complex

Hassan Hashimi, Sara L. Zimmer, Michelle L. Ammerman, Laurie K. Read, Julius Lukeš

Research output: Contribution to journalArticlepeer-review

49 Scopus citations

Abstract

Our understanding of kinetoplastid RNA (kRNA) editing has centered on this paradigm: guide RNAs (gRNAs) provide a blueprint for uridine insertion/deletion into mitochondrial mRNAs by the RNA editing core complex (RECC). The characterization of constituent subunits of the mitochondrial RNA-binding complex 1 (MRB1) implies that it too is vital to the editing process. The recently elucidated MRB1 architecture will be instrumental in putting functional data from individual subunits into context. Our model depicts two functions for MRB1: mediating multi-round kRNA editing by coordinating the exchange of multiple gRNAs required by RECC to edit lengthy regions of mRNAs, and then linking kRNA editing with other RNA processing events.

Original languageEnglish (US)
Pages (from-to)91-99
Number of pages9
JournalTrends in Parasitology
Volume29
Issue number2
DOIs
StatePublished - Feb 2013

Bibliographical note

Funding Information:
This work was supported by the Grant Agency of the Czech Republic (204/09/1667 and P305/12/2261), the RNPnet FP7 program (289007), a Praemium Academiae award to J.L., as well as National Institutes of Health awards RO1 AI061580 to L.K.R. and F32 AI092902 to S.L.Z.. J.L. is a Fellow of the Canadian Institute for Advanced Research.

Keywords

  • Kinetoplastida
  • MRB1
  • Protein complexes
  • RECC
  • RNA editing
  • Trypanosome

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