DTI and impulsivity in schizophrenia: A first voxelwise correlational analysis

Matthew J. Hoptman; Babak A. Ardekani; Pamela D. Butler; Jay Nierenberg; Daniel C. Javitt; Kelvin O. Lim

doi:10.1097/00001756-200411150-00007

DTI and impulsivity in schizophrenia: A first voxelwise correlational analysis

Matthew J. Hoptman, Babak A. Ardekani, Pamela D. Butler, Jay Nierenberg, Daniel C. Javitt, Kelvin O. Lim

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Abstract

Compromised white matter (WM) integrity in inferior frontal WM has been related to impulsivity in men with schizophrenia. However, these relationships may be more widespread. Fractional anisotropy (FA) derived from diffusion tensor imaging of 25 men with schizophrenia was transformed intoTalairach space. Correlations between FA and impulsiveness were examined on a voxelwise basis. We found negative correlations between FA and impulsivity in inferior frontal WM, anterior cingulate, caudate, insula, and inferior parietal lobule. Positive correlations were obtained in the left postcentral gyrus, right superior/middle temporal gyrus, and bilateral fusiform gyrus. These areas may comprise a fronto-temporo-limbic circuit that modulates impulsivity. The voxelwise correlation method can serve as a hypothesis-generation method for relating target behaviors to their underlying neural networks.

Original language	English (US)
Pages (from-to)	2467-2470
Number of pages	4
Journal	Neuroreport
Volume	15
Issue number	16
DOIs	https://doi.org/10.1097/00001756-200411150-00007
State	Published - Dec 15 2004

Keywords

Diffusion tensor imaging
Impulsivity
Schizophrenia

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10.1097/00001756-200411150-00007

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title = "DTI and impulsivity in schizophrenia: A first voxelwise correlational analysis",

abstract = "Compromised white matter (WM) integrity in inferior frontal WM has been related to impulsivity in men with schizophrenia. However, these relationships may be more widespread. Fractional anisotropy (FA) derived from diffusion tensor imaging of 25 men with schizophrenia was transformed intoTalairach space. Correlations between FA and impulsiveness were examined on a voxelwise basis. We found negative correlations between FA and impulsivity in inferior frontal WM, anterior cingulate, caudate, insula, and inferior parietal lobule. Positive correlations were obtained in the left postcentral gyrus, right superior/middle temporal gyrus, and bilateral fusiform gyrus. These areas may comprise a fronto-temporo-limbic circuit that modulates impulsivity. The voxelwise correlation method can serve as a hypothesis-generation method for relating target behaviors to their underlying neural networks.",

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T2 - A first voxelwise correlational analysis

AU - Hoptman, Matthew J.

AU - Ardekani, Babak A.

AU - Butler, Pamela D.

AU - Nierenberg, Jay

AU - Javitt, Daniel C.

AU - Lim, Kelvin O.

PY - 2004/12/15

Y1 - 2004/12/15

N2 - Compromised white matter (WM) integrity in inferior frontal WM has been related to impulsivity in men with schizophrenia. However, these relationships may be more widespread. Fractional anisotropy (FA) derived from diffusion tensor imaging of 25 men with schizophrenia was transformed intoTalairach space. Correlations between FA and impulsiveness were examined on a voxelwise basis. We found negative correlations between FA and impulsivity in inferior frontal WM, anterior cingulate, caudate, insula, and inferior parietal lobule. Positive correlations were obtained in the left postcentral gyrus, right superior/middle temporal gyrus, and bilateral fusiform gyrus. These areas may comprise a fronto-temporo-limbic circuit that modulates impulsivity. The voxelwise correlation method can serve as a hypothesis-generation method for relating target behaviors to their underlying neural networks.

AB - Compromised white matter (WM) integrity in inferior frontal WM has been related to impulsivity in men with schizophrenia. However, these relationships may be more widespread. Fractional anisotropy (FA) derived from diffusion tensor imaging of 25 men with schizophrenia was transformed intoTalairach space. Correlations between FA and impulsiveness were examined on a voxelwise basis. We found negative correlations between FA and impulsivity in inferior frontal WM, anterior cingulate, caudate, insula, and inferior parietal lobule. Positive correlations were obtained in the left postcentral gyrus, right superior/middle temporal gyrus, and bilateral fusiform gyrus. These areas may comprise a fronto-temporo-limbic circuit that modulates impulsivity. The voxelwise correlation method can serve as a hypothesis-generation method for relating target behaviors to their underlying neural networks.

KW - Diffusion tensor imaging

KW - Impulsivity

KW - Schizophrenia

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SP - 2467

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JO - Neuroreport

JF - Neuroreport

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ER -

DTI and impulsivity in schizophrenia: A first voxelwise correlational analysis

Abstract

Keywords

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