DTI and impulsivity in schizophrenia: A first voxelwise correlational analysis

Matthew J. Hoptman, Babak A. Ardekani, Pamela D. Butler, Jay Nierenberg, Daniel C. Javitt, Kelvin O. Lim

Research output: Contribution to journalArticlepeer-review

91 Scopus citations


Compromised white matter (WM) integrity in inferior frontal WM has been related to impulsivity in men with schizophrenia. However, these relationships may be more widespread. Fractional anisotropy (FA) derived from diffusion tensor imaging of 25 men with schizophrenia was transformed intoTalairach space. Correlations between FA and impulsiveness were examined on a voxelwise basis. We found negative correlations between FA and impulsivity in inferior frontal WM, anterior cingulate, caudate, insula, and inferior parietal lobule. Positive correlations were obtained in the left postcentral gyrus, right superior/middle temporal gyrus, and bilateral fusiform gyrus. These areas may comprise a fronto-temporo-limbic circuit that modulates impulsivity. The voxelwise correlation method can serve as a hypothesis-generation method for relating target behaviors to their underlying neural networks.

Original languageEnglish (US)
Pages (from-to)2467-2470
Number of pages4
Issue number16
StatePublished - Dec 15 2004


  • Diffusion tensor imaging
  • Impulsivity
  • Schizophrenia


Dive into the research topics of 'DTI and impulsivity in schizophrenia: A first voxelwise correlational analysis'. Together they form a unique fingerprint.

Cite this