Drugging the microbiome: targeting small microbiome molecules

Sachin Sharma, Pooja V Hegde, Subhankar Panda, Moyosore O Orimoloye, Courtney C. Aldrich

Research output: Contribution to journalReview articlepeer-review

Abstract

The human microbiome represents a large and diverse collection of microbes that plays an integral role in human physiology and pathophysiology through interactions with the host and within the microbial community. While early work exploring links between microbiome signatures and diseases states has been associative, emerging evidence demonstrates the metabolic products of the human microbiome have more proximal causal effects on disease phenotypes. The therapeutic implications of this shift are profound as manipulation of the microbiome by the administration of live biotherapeutics, ongoing, can now be pursued alongside research efforts toward describing inhibitors of key microbiome enzymes involved in the biosynthesis of metabolites implicated in various disease states and processing of host-derived metabolites. With growing interest in ‘drugging the microbiome’, we review few notable microbial metabolites for which traditional drug-development campaigns have yielded compounds with therapeutic promise.

Original languageEnglish (US)
Article number102234
JournalCurrent Opinion in Microbiology
Volume71
DOIs
StatePublished - Feb 2023

Bibliographical note

Funding Information:
This work was supported by grants ( AI143784 and AI136445 ) from the National Institutes of Health .

Publisher Copyright:
© 2022 Elsevier Ltd

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