Drug release and biodegradability of electrospun cellulose nanocrystal reinforced polycaprolactone

Ahmad Hivechi, S. Hajir Bahrami, Ronald A Siegel

Research output: Contribution to journalArticle

Abstract

In this paper, high molecular weight cellulose was used as the starting material for the synthesis of cellulose nanocrystal (CNC). Different analysis techniques such as FTIR, XRD, TGA, DLS, and AFM were used to characterize CNC synthesis. The synthesized CNC was incorporated in polycaprolactone solution and nanofibers were prepared under different conditions. Production conditions were optimized based on the diameter of nanofibers using response surface methodology (RSM). Based on our results, the optimal condition is electrospinning of 16% PCL polymer solution at 17 kV and a 0.9 ml/h feed rate, which yields nanofibers with a diameter of 233 nm. The effects of CNC content on morphological, mechanical and thermal properties were investigated. Results also showed that CNC incorporation in PCL nanofibers enhances biodegradability. SEM, DSC, tensile, and biodegradability results showed that the nanofibers prepared from PCL solution containing 1% CNC have optimal mechanical and degradation behaviors. We also studied and modeled release of tetracycline from nanofiber mats, based on the assumption of rate limiting diffusion from the nanofibers, with a fraction of release delayed by drug sequestration. Results showed that the final drug release is decreased in CNC-incorporated nanofibers.

LanguageEnglish (US)
Pages929-937
Number of pages9
JournalMaterials Science and Engineering C
Volume94
DOIs
StatePublished - Jan 1 2019

Fingerprint

biodegradability
Polycaprolactone
Biodegradability
Nanofibers
cellulose
Cellulose
Nanocrystals
nanocrystals
drugs
Pharmaceutical Preparations
tetracyclines
polycaprolactone
Electrospinning
synthesis
Polymer solutions
Tetracycline
molecular weight
Thermodynamic properties
thermodynamic properties
Molecular weight

Keywords

  • Biodegradability
  • Cellulose nanocrystal
  • Drug release
  • Electrospinning
  • Polycaprolactone
  • Response surface methodology

Cite this

Drug release and biodegradability of electrospun cellulose nanocrystal reinforced polycaprolactone. / Hivechi, Ahmad; Bahrami, S. Hajir; Siegel, Ronald A.

In: Materials Science and Engineering C, Vol. 94, 01.01.2019, p. 929-937.

Research output: Contribution to journalArticle

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