Drug-induced urolithiasis

C. A. Osborne, J. P. Lulich, J. W. Bartges, L. K. Ulrich, L. A. Koehler, K. A. Bird, L. L. Swanson, G. W. Austin, Jr Prien, K. U. Steinam

Research output: Contribution to journalReview article

19 Scopus citations

Abstract

Diagnostic and therapeutic drugs may enhance urolithiasis in one or a combination of ways, including: (1) alteration of urine pH in such fashion as to create an environment that increases the solubility of some lithogenic substances, (2) alteration of glomerular filtration rate, tubular reabsorption, and tubular secretion of drugs of endogenous substances so as to enhance promoters or impair inhibitors of urolithiasis, and (3) precipitation (e.g., drugs or their metabolites) to form a portion or all of a urolith.

Original languageEnglish (US)
Pages (from-to)251-266
Number of pages16
JournalVeterinary Clinics of North America - Small Animal Practice
Volume29
Issue number1
DOIs
StatePublished - Jan 1 1999

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