Drug addiction and chronic pain

A review of animal models

Carrie L. Wade, George F. Koob, Leandro F. Vendruscolo

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

1 Citation (Scopus)

Abstract

Animal models of pain play an important role in the characterization and development of therapeutics for several pain conditions. Models that mimic the development and maintenance of chronic pain conditions are especially important and have directly impacted the availability of treatments for many common pain conditions such as neuropathic, inflammatory, and visceral. The most efficacious and first choice treatment option for chronic pain is opioid analgesics. Besides being potent analgesics, opioids produce an intense pleasant feeling (reward), especially in individuals not suffering actual pain. This raises the concern that the chronic treatment of pain with opioids can cause opioid tolerance and dependence. This chapter discusses the animal models that are used to quantitatively measure nociception and analgesia, and animal models that are used to study inflammatory, neuropathic, and visceral pain. Additionally, we discuss the animal models used to study opioid dependence.

Original languageEnglish (US)
Title of host publicationContemporary Clinical Neuroscience
Subtitle of host publicationNeurobiological Studies of Addiction in Chronic Pain States
PublisherSpringer New York
Pages61-79
Number of pages19
Volume17
ISBN (Electronic)9781493918560
ISBN (Print)9781493918553
DOIs
StatePublished - Nov 16 2014

Fingerprint

Chronic Pain
Opioid Analgesics
Substance-Related Disorders
Animal Models
Pain
Visceral Pain
Nociception
Neuralgia
Therapeutics
Reward
Analgesia
Emotions
Maintenance

Cite this

Wade, C. L., Koob, G. F., & Vendruscolo, L. F. (2014). Drug addiction and chronic pain: A review of animal models. In Contemporary Clinical Neuroscience: Neurobiological Studies of Addiction in Chronic Pain States (Vol. 17, pp. 61-79). Springer New York. https://doi.org/10.1007/978-1-4939-1856-0_5

Drug addiction and chronic pain : A review of animal models. / Wade, Carrie L.; Koob, George F.; Vendruscolo, Leandro F.

Contemporary Clinical Neuroscience: Neurobiological Studies of Addiction in Chronic Pain States. Vol. 17 Springer New York, 2014. p. 61-79.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Wade, CL, Koob, GF & Vendruscolo, LF 2014, Drug addiction and chronic pain: A review of animal models. in Contemporary Clinical Neuroscience: Neurobiological Studies of Addiction in Chronic Pain States. vol. 17, Springer New York, pp. 61-79. https://doi.org/10.1007/978-1-4939-1856-0_5
Wade CL, Koob GF, Vendruscolo LF. Drug addiction and chronic pain: A review of animal models. In Contemporary Clinical Neuroscience: Neurobiological Studies of Addiction in Chronic Pain States. Vol. 17. Springer New York. 2014. p. 61-79 https://doi.org/10.1007/978-1-4939-1856-0_5
Wade, Carrie L. ; Koob, George F. ; Vendruscolo, Leandro F. / Drug addiction and chronic pain : A review of animal models. Contemporary Clinical Neuroscience: Neurobiological Studies of Addiction in Chronic Pain States. Vol. 17 Springer New York, 2014. pp. 61-79
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