Drug addiction and chronic pain: A review of animal models

Carrie L. Wade, George F. Koob, Leandro F. Vendruscolo

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)peer-review

2 Scopus citations


Animal models of pain play an important role in the characterization and development of therapeutics for several pain conditions. Models that mimic the development and maintenance of chronic pain conditions are especially important and have directly impacted the availability of treatments for many common pain conditions such as neuropathic, inflammatory, and visceral. The most efficacious and first choice treatment option for chronic pain is opioid analgesics. Besides being potent analgesics, opioids produce an intense pleasant feeling (reward), especially in individuals not suffering actual pain. This raises the concern that the chronic treatment of pain with opioids can cause opioid tolerance and dependence. This chapter discusses the animal models that are used to quantitatively measure nociception and analgesia, and animal models that are used to study inflammatory, neuropathic, and visceral pain. Additionally, we discuss the animal models used to study opioid dependence.

Original languageEnglish (US)
Title of host publicationContemporary Clinical Neuroscience
Subtitle of host publicationNeurobiological Studies of Addiction in Chronic Pain States
PublisherSpringer New York
Number of pages19
ISBN (Electronic)9781493918560
ISBN (Print)9781493918553
StatePublished - Nov 16 2014

Bibliographical note

Publisher Copyright:
© Springer Science+Business Media New York 2014.


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