DQ β sequences in HLA-DR4 haplotypes

J. M. Hilden; J. M. Curtsinger; J. S. Cairns; F. H. Bach

doi:10.1016/0198-8859(87)90073-5

DQ β sequences in HLA-DR4 haplotypes

J. M. Hilden, J. M. Curtsinger, J. S. Cairns, F. H. Bach

Masonic Cancer Center

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

A cDNA clone encoding the entire mature DQ β chain was isolated and sequenced from the DR4-Dw14 homozygous cell line, LS40. The sequence was compared with published DQ β sequences from cells expressing DR4-DQw3, and found to be identical. The lack of DQ β sequence polymorphism within this serotype (to date, DQ β sequences have been derived from five cell lines comprising three Dw subtypes) adds to the data that suggest a recent evolutionary divergence of Dw subtypes within DR4-DQw3.

Original language	English (US)
Pages (from-to)	261-264
Number of pages	4
Journal	Human Immunology
Volume	18
Issue number	4
DOIs	https://doi.org/10.1016/0198-8859(87)90073-5
State	Published - Apr 1987

Publisher link

10.1016/0198-8859(87)90073-5

Find It

Find It at U of M Libraries

Cite this

@article{d89df6cea8d44a0c9aeab3bb7c47a359,

title = "DQ β sequences in HLA-DR4 haplotypes",

abstract = "A cDNA clone encoding the entire mature DQ β chain was isolated and sequenced from the DR4-Dw14 homozygous cell line, LS40. The sequence was compared with published DQ β sequences from cells expressing DR4-DQw3, and found to be identical. The lack of DQ β sequence polymorphism within this serotype (to date, DQ β sequences have been derived from five cell lines comprising three Dw subtypes) adds to the data that suggest a recent evolutionary divergence of Dw subtypes within DR4-DQw3.",

author = "Hilden, {J. M.} and Curtsinger, {J. M.} and Cairns, {J. S.} and Bach, {F. H.}",

year = "1987",

month = apr,

doi = "10.1016/0198-8859(87)90073-5",

language = "English (US)",

volume = "18",

pages = "261--264",

journal = "Human Immunology",

issn = "0198-8859",

publisher = "Elsevier Inc.",

number = "4",

}

TY - JOUR

T1 - DQ β sequences in HLA-DR4 haplotypes

AU - Hilden, J. M.

AU - Curtsinger, J. M.

AU - Cairns, J. S.

AU - Bach, F. H.

PY - 1987/4

Y1 - 1987/4

N2 - A cDNA clone encoding the entire mature DQ β chain was isolated and sequenced from the DR4-Dw14 homozygous cell line, LS40. The sequence was compared with published DQ β sequences from cells expressing DR4-DQw3, and found to be identical. The lack of DQ β sequence polymorphism within this serotype (to date, DQ β sequences have been derived from five cell lines comprising three Dw subtypes) adds to the data that suggest a recent evolutionary divergence of Dw subtypes within DR4-DQw3.

AB - A cDNA clone encoding the entire mature DQ β chain was isolated and sequenced from the DR4-Dw14 homozygous cell line, LS40. The sequence was compared with published DQ β sequences from cells expressing DR4-DQw3, and found to be identical. The lack of DQ β sequence polymorphism within this serotype (to date, DQ β sequences have been derived from five cell lines comprising three Dw subtypes) adds to the data that suggest a recent evolutionary divergence of Dw subtypes within DR4-DQw3.

UR - http://www.scopus.com/inward/record.url?scp=0023180630&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023180630&partnerID=8YFLogxK

U2 - 10.1016/0198-8859(87)90073-5

DO - 10.1016/0198-8859(87)90073-5

M3 - Article

C2 - 3494717

AN - SCOPUS:0023180630

SN - 0198-8859

VL - 18

SP - 261

EP - 264

JO - Human Immunology

JF - Human Immunology

IS - 4

ER -

DQ β sequences in HLA-DR4 haplotypes

Abstract

Publisher link

Find It

Other files and links

Fingerprint

Cite this