DQ β sequences in HLA-DR4 haplotypes

J. M. Hilden, J. M. Curtsinger, J. S. Cairns, F. H. Bach

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

A cDNA clone encoding the entire mature DQ β chain was isolated and sequenced from the DR4-Dw14 homozygous cell line, LS40. The sequence was compared with published DQ β sequences from cells expressing DR4-DQw3, and found to be identical. The lack of DQ β sequence polymorphism within this serotype (to date, DQ β sequences have been derived from five cell lines comprising three Dw subtypes) adds to the data that suggest a recent evolutionary divergence of Dw subtypes within DR4-DQw3.

Original languageEnglish (US)
Pages (from-to)261-264
Number of pages4
JournalHuman Immunology
Volume18
Issue number4
DOIs
StatePublished - Apr 1987

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