Doxorubicin chemomyectomy: Effects on evoked vocal fold tension and mucosal wave

George S. Goding, Kerri J. Pernell

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Chemomyectomy of the thyroarytenoid muscle is a potential alternative approach to the management of spasmodic dysphonia (laryngeal dystonia) that could provide a prolonged response. To be useful, chemomyectomy should produce weakening of vocal fold closure without disruption of the mucosal wave. Sixteen dogs were studied. In 8 animals, doxorubicin hydrochloride (3 mg) and verapamil hydrochloride (0.5 mg) were injected unilaterally into the thyroarytenoid muscle 2 months before evaluation. The remaining animals served as noninjected controls. Injection of doxorubicin and verapamil decreased the average evoked tension of the vocal fold by 74.7%, compared to an average side-to-side difference of 12.7% in the control group (p = .001). A mucosal wave was recognized bilaterally with videostroboscopy in all dogs. Doxorubicin did not significantly change the vocal fold appearance or mucosal wave amplitude. These results support further laboratory study of chemomyectomy as a potential alternative treatment for laryngeal dystonia.

Original languageEnglish (US)
Pages (from-to)294-300
Number of pages7
JournalAnnals of Otology, Rhinology and Laryngology
Issue number3
StatePublished - 2000
Externally publishedYes


  • Doxorubicin
  • Larynx
  • Spasmodic dysphonia
  • Vocal fold


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