Doxorubicin accumulation in individually electrophoresed organelles

Adrian B. Anderson; Guohua Xiong; Edgar A. Arriaga

doi:10.1021/ja0492539

Doxorubicin accumulation in individually electrophoresed organelles

Adrian B. Anderson, Guohua Xiong, Edgar A. Arriaga

Chemistry (Twin Cities)

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

We report the doxorubicin content in individual organelles following their capillary electrophoretic separation and illustrate that chemical accumulation at the subcellular level is highly heterogeneous. In individual mitochondria from cultured human leukemia cells DOX amount is around 50 zmol, 2 orders of magnitude higher than expected from diffusion during drug treatment, and spans 2 orders of magnitude.

Original language	English (US)
Pages (from-to)	9168-9169
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	126
Issue number	30
DOIs	https://doi.org/10.1021/ja0492539
State	Published - Aug 4 2004

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title = "Doxorubicin accumulation in individually electrophoresed organelles",

abstract = "We report the doxorubicin content in individual organelles following their capillary electrophoretic separation and illustrate that chemical accumulation at the subcellular level is highly heterogeneous. In individual mitochondria from cultured human leukemia cells DOX amount is around 50 zmol, 2 orders of magnitude higher than expected from diffusion during drug treatment, and spans 2 orders of magnitude.",

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AU - Xiong, Guohua

AU - Arriaga, Edgar A.

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AB - We report the doxorubicin content in individual organelles following their capillary electrophoretic separation and illustrate that chemical accumulation at the subcellular level is highly heterogeneous. In individual mitochondria from cultured human leukemia cells DOX amount is around 50 zmol, 2 orders of magnitude higher than expected from diffusion during drug treatment, and spans 2 orders of magnitude.

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Doxorubicin accumulation in individually electrophoresed organelles

Abstract

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