Doxorubicin accumulation in individually electrophoresed organelles

Adrian B. Anderson, Guohua Xiong, Edgar A. Arriaga

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

We report the doxorubicin content in individual organelles following their capillary electrophoretic separation and illustrate that chemical accumulation at the subcellular level is highly heterogeneous. In individual mitochondria from cultured human leukemia cells DOX amount is around 50 zmol, 2 orders of magnitude higher than expected from diffusion during drug treatment, and spans 2 orders of magnitude.

Original languageEnglish (US)
Pages (from-to)9168-9169
Number of pages2
JournalJournal of the American Chemical Society
Volume126
Issue number30
DOIs
StatePublished - Aug 4 2004

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